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Platelet DysfunctionAka: Platelet Bleeding Disorder, Thrombasthenia

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  1. See Also
    1. Thrombocytopenia
    2. Bleeding Disorder
    3. Drug Induced Platelet Dysfunction
    4. Coagulation Bleeding Disorders
    5. Bleeding Disorder
    6. Blood Vessel Wall Bleeding Disorders
    7. Coagulopathy in Pregnancy
    8. Clotting Pathway
  2. Signs
    1. Bleeding Disorders
    2. Purpura or Petechiae
  3. Causes: Congenital Platelet Dysfunction
    1. Von Willebrand's Disease
    2. Glanzmann's Thrombasthenia (autosomal recessive)
      1. Platelet membrane deficiency Glycoprotein IIb, IIIa
      2. Defective binding of platelet Fibrinogen
      3. Decreased platelet aggregation
    3. Bernard-Soulier Disease (autosomal recessive)
      1. Platelet membrane deficiency Glycoprotein Ib
      2. Coagulation Factor X and Factor V deficiency
      3. Large platelets and decreased platelet aggregation
    4. Storage Pool Disease
      1. Dense granule and/or alpha granule deficiency
      2. Defective platelet release of ADP and Serotonin
  4. Causes: Acquired Platelet Dysfunction
    1. See Drug Induced Platelet Dysfunction
    2. See Thrombocytopenia
      1. Idiopathic Thrombocytopenic Purpura
      2. Thrombotic Thrombocytopenic Purpura
    3. Uremia
    4. Chronic Liver Disease

Thrombasthenia (C0040015)

Definition (MSH)A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
Definition (CSP)platelet abnormality characterized by defective clot formation, impaired aggregation, and prolonged bleeding time; other manifestations include nosebleeds, inappropriate bruising, and excessive bleeding.
ConceptsDisease or Syndrome (T047)
ICD9287.1
MSHD013915
EnglishGLANZMANN DISEASE, Glanzmann Thrombasthenia, Glanzmann thromboasthenia, Glanzmann's disease, Glanzmann's syndrome, Glanzmann's thrombasthenia, Glanzmann-Naegeli disorder, Glanzsmann's disease, Glycoprotein IIb/IIIa defect, GT, Hereditary haemorrhagic thrombasthenia, Hereditary hemorrhagic thrombasthenia, Hereditary thromboasthenia, PLATELET GLYCOPROTEIN IIb-IIIa DEFICIENCY, Thrombasthenia, THROMBASTHENIA OF GLANZMANN AND NAEGELI, Thrombasthenias, Thromboasthenia, Thrombocytasthenia
Spanishtrastorno de Glanzmann - Naegeli, trombastenia de Glanzmann, tromboastenia, tromboastenia de Glanzmann, tromboastenia hereditaria
Parent ConceptsBlood Platelet Disorders (C0005818), Hemorrhagic Disorders (C0019087), Blood Coagulation Disorders, Inherited (C0852077), Non-Neoplastic Hematologic and Lymphocytic Disorder (C1518374), Blood Coagulation Disorders (C0005779), Platelet membrane defect (C0398628), Hereditary platelet function disorder (C1264033), Duplicate concept (C1274013)
SourcesCSP, CST, DXP, MSH, MTH, MTHICD9, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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