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Plant Alkaloid Chemotherapy

Mechanism
1. Vinca alkaloids
  1. Inhibits mitosis (metaphase arrest)
  2. Cause disassembly of microtubules
2. Podophyllotoxins
  1. Block cells in S-G2 phase of cell cycle
  2. DNA degradation
  3. Nucleoside transport inhibition
  4. Mitochondrial electron transport inhibition
Agents
1. Periwinkle Plant (Vinca rosea) derivative
  1. Vinblastine (Velban)
  2. Vincristine (Oncovin)
2. Mayapple plant (Podophyllum peltatum) derivative
  1. Etoposide (VP-16)
  2. Teniposide (VM-26)

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Plant Alkaloid Chemotherapy

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