Hematology and Oncology Book

http://www.fpnotebook.com/

Heparin Induced Thrombocytopenia

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  1. Background
    1. Immune mediated disorder
      1. Antibody against Heparin-platelet factor 4 complex
    2. Onset 4-10 days after Heparin exposure
      1. Onset earlier with prior Heparin exposure
    3. Two types
      1. Type I is mild, and just requires monitoring
      2. Type II is severe, life-threatening
  2. Epidemiology
    1. Incidence: 0.2 to 3% of those on Heparin >4 days
      1. LMWH is much less likely (only 1/6 of Heparin risk)
  3. Signs
    1. Type II HIT is a clinically devastating event
    2. Associated with DIC-type findings
  4. Labs
    1. Platelet Count
      1. Marked and sudden Thrombocytopenia

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