Hematology and Oncology Book

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Hydroxyurea

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  1. Mechanism
    1. Increases production of fetal Hemoglobin (HbF)
  2. Indications
    1. Indicated for 3 or more crises per year, over age 18
  3. Monitoring
    1. Baseline
      1. Complete Blood Count
      2. Reticulocyte Count
      3. Hemoglobin F
      4. Renal Function tests
      5. Liver Function Tests
      6. Pregnancy Test
    2. Follow-up labs (periodically and with dose change)
      1. Complete Blood Count
      2. Renal Function tests
      3. Liver Function Tests
      4. Hemoglobin F
  4. Efficacy
    1. Reduces Sickle Cell Crisis by 50%
    2. Reduces Sickle Cell Anemia mortality
      1. Steinberg (2003) JAMA 289:1645

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