Hematology and Oncology Book

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Glycoprotein IIB/IIIA InhibitorAka: GP IIB/IIA Inhibitor, Abciximab, ReoPro, Tirofiban, Aggrastat, Eptifibatide, Integrilin

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  1. Indications
    1. Non-Q-Wave Myocardial Infarction
    2. High risk Unstable Angina
    3. Angioplasty
  2. Mechanism
    1. Inhibits platelet aggregation
  3. Dosing: Abciximab (ReoPro)
    1. Load: 0.25 mg/kg IV bolus
    2. Infuse: 0.125 ug/kg/min up to 10 ug/min IV x12 hours
  4. Dosing: Eptifibatide (Integrilin)
    1. Acute Coronary Syndrome
      1. Load: 180 ug/kg
      2. Infuse: 2 ug/kg/min IV x72 hours
    2. Angioplasty
      1. Load: 135 ug/kg IV before procedure
      2. Infuse: 0.5 ug/kg/min IV x24 hours
  5. Dosing: Tirofiban (Aggrastat)
    1. Load: 0.4 ug/kg/min for 30 minutes
    2. Infuse: 0.1 ug/kg/min
    3. Infusion duration
      1. Acute Coronary Syndrome: 48 to 108 hours
      2. Angioplasty: 12 to 24 hours

tirofiban (C0247025)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishtirofiban, TIROFIBAN PREPARATION
Spanishtirofibán, tirofiban
CreditsDerived from the NIH UMLS (Unified Medical Language System)


eptifibatide (C0253563)

Definition (NCI)A cyclical heptapeptide with anticoagulant activity. Eptifibatide selectively and reversibly binds to and blocks the platelet glycoprotein IIb/IIIa receptor. This prevents the binding of fibrinogen, von Willebrand factor, and other adhesive ligands and leads to an inhibition of platelet aggregation and prevents thrombus development.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
Englishepifibatide, epifibratide, eptifibatide, EPTIFIBATIDE PREPARATION
Spanisheptifibatida
CreditsDerived from the NIH UMLS (Unified Medical Language System)


abciximab (C0288672)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
Englishabciximab, ABCIXIMAB PREPARATION, c7E3 Fab, chimeric 7E3 Fab
Spanishabciximab
CreditsDerived from the NIH UMLS (Unified Medical Language System)


ReoPro (C0592046)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishEli Lilly brand of abciximab, Lilly brand of abciximab, ReoPro
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Aggrastat (C0656369)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishAggrastat, Agrastat, Cahill May Roberts brand of tirofiban hydrochloride monohydrate, Merck brand of tirofiban hydrochloride monohydrate, Merck Frosst brand of tirofiban hydrochloride monohydrate, Merck Sharp & Dohme brand of tirofiban hydrochloride monohydrate, MSD brand of tirofiban hydrochloride monohydrate
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Integrilin (C0950902)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishCor brand of eptifibatide, Essex brand of eptifibatide, integrelin, Integrilin, Key brand of eptifibatide, Pharmacia brand of eptifibatide
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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