Hematology and Oncology Book

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ErythropoietinAka: Epoetin, Procrit, Epogen

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  1. Indications
    1. Illicit use by athletes as ergonomic aid (banned)
    2. Anemia
      1. Chronic Renal Failure
        1. Indicated to maintain Hematocrit 33-36%
        2. Decreases cardiovascular morbidity and mortality
        3. Increases quality of life
      2. Cancer Chemotherapy
        1. Indicated to maintain Hemoglobin >12 g/dl
        2. Contraindicated if serum erythropoietin >200 mU/ml
        3. Increases Hemoglobin 2 g/dl
        4. Decreases transfusion need
        5. Increases quality of life
        6. Does not improve survival or delay disease progress
          1. Henke (2003) Lancet 362:1255
      3. Anemia secondary to HIV Management (e.g. Zidovudine)
        1. Contraindicated if serum erythropoietin >500 mU/ml
        2. Increases quality of life (e.g. Energy)
        3. Prolongs AIDS survival
      4. Prophylaxis before elective surgery (non-cardiac)
        1. Indicated for Hemoglobin <13 g/dl before surgery
        2. Decreases transfusion need
  2. Adverse effects
    1. Hypertension (25% of Renal Failure patients)
      1. Hypertensive encephalopathy
      2. Seizures
    2. Thrombotic events (e.g. Myocardial Infarction)
    3. May promote growth of certain Breast Cancers
  3. Disadvantages
    1. See adverse effects above
    2. Cost: $3000 for 8 week cancer course
  4. References
    1. (2001) Med Lett Drugs Ther 43(1104):40
    2. (2001) Am J Kidney Dis 37(suppl 1):S182
    3. Andrade (1996) Am J Orthop 25:533
    4. Demetri (1998) J Clin Oncol 16:3412
    5. Henry (1992) Ann Intern Med 117:739
    6. Moore (1999) Clin Infect Dis 29:44
    7. Tsakiris (2000) Nephron 85(suppl 1):2

Erythropoietin (C0014822)

Definition (MSH)Glycoprotein hormone, secreted chiefly by the kidney in the adult and the liver in the fetus, that acts on erythroid stem cells of the bone marrow to stimulate proliferation and differentiation.
Definition (CSP)glycoprotein hormone, secreted chiefly by the kidney in the adult and the liver in the fetus, that acts on erythroid stem cells of the bone marrow to stimulate proliferation and differentiation.
Definition (NCI)Produced in the adult kidney, a colony-stimulating factor that stimulates the production of red blood cells.
Definition (NCI)Human erythropoietin is an acidic glycoprotein hormone with a molecular mass of 34 kD. As the prime regulator of red cell production, its major functions are to promote erythroid differentiation and to initiate hemoglobin synthesis.[supplied by OMIM](LocusLink)
ConceptsAmino Acid, Peptide, or Protein (T116) , Hormone (T125)
EnglishECSF, EPO, Epoetin, erythrocyte colony stimulating factor, Erythropoietin, Erythropoietin preparation, Erythropoietin product, Hematopoietin
Spanisheritropoyetina, hematopoyetina, hemopoyetina, hormona eritropoyética, hormona eritropoyetica, preparado con eritropoyetina, preparado de eritropoyetina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Epogen (C0700704)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125) , Immunologic Factor (T129)
EnglishEpogen
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Procrit (C0733467)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishProcrit
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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