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Drug Induced Platelet DysfunctionAka: Drug Induced Platelet Destruction, Drug induced Thrombocytopenia
- See Also
- Platelet Bleeding Disorders
- Thrombocytopenia
- Causes: Thrombocytopenia
- Chemotherapeutic agents
- Antibiotics
- Sulfonamides (e.g. Bactrim)
- Beta Lactam antibiotics (Penicillins)
- Cardiovascular Agents
- Digoxin
- Methyldopa
- Procainamide
- Quinidine
- Quinine
- Thiazide Diuretics
- H2 Antagonists (Cimetidine, Ranitidine)
- Neuropsych agents
- Barbiturates
- Phenytoin (Dilantin)
- Valproic Acid (Depakene)
- Miscellanous Agents
- Alcoholism
- Estrogens
- Gold
- Heparin (5% of patients on >5 days Heparin)
- In vivo platelet aggregation
- Propylthiouracil
- Causes: Platelet impaired function
- Common causes
- Consider agents that affect coagulation (Heparin, Warfarin)
- Aspirin
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- Clopidogrel (Plavix)
- Other causes
- Antidepressants
- Tricyclic Antidepressants
- Selective Serotonin Reuptake Inhibitors
- Antihistamines
- Azatadine
- Brompheniramine
- Clemastine fumarate
- Clofibrate
- Dipyridamole
- Furosemide (Lasix)
- Ginkgo Biloba
- Nitrofurantoin (Furadantin)
- Propranolol
- Sulfinpyrazone
- Management
- Discontinue offending agent
- Course
- Expect recovery in 7-10 days
- Medications
- Sympathetic blockers
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