Hematology and Oncology Book

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Drug Induced Platelet Dysfunction

Aka: Drug Induced Platelet Dysfunction, Drug Induced Platelet Destruction, Drug induced Thrombocytopenia
  1. See Also
    1. Platelet Bleeding Disorders
    2. Thrombocytopenia
  2. Causes: Thrombocytopenia
    1. Chemotherapeutic agents
    2. Antibiotics
      1. Sulfonamides (e.g. Bactrim)
      2. Beta Lactam antibiotics (Penicillins)
    3. Cardiovascular Agents
      1. Digoxin
      2. Methyldopa
      3. Procainamide
      4. Quinidine
      5. Quinine
      6. Thiazide Diuretics
    4. H2 Antagonists (Cimetidine, Ranitidine)
    5. Neuropsych agents
      1. Barbiturates
      2. Phenytoin (Dilantin)
      3. Valproic Acid (Depakene)
    6. Miscellanous Agents
      1. Alcoholism
      2. Estrogens
      3. Gold
      4. Heparin (5% of patients on >5 days Heparin)
        1. In vivo platelet aggregation
      5. Propylthiouracil
  3. Causes: Platelet impaired function
    1. Common causes
      1. Consider agents that affect coagulation (Heparin, Warfarin)
      2. Aspirin
      3. Nonsteroidal Antiinflammatory Drugs (NSAIDs)
      4. Clopidogrel (Plavix)
    2. Other causes
      1. Antidepressants
        1. Tricyclic Antidepressants
        2. Selective Serotonin Reuptake Inhibitors
      2. Antihistamines
        1. Azatadine
        2. Brompheniramine
        3. Clemastine fumarate
      3. Clofibrate
      4. Dipyridamole
      5. Furosemide (Lasix)
      6. Ginkgo Biloba
      7. Nitrofurantoin (Furadantin)
      8. Propranolol
      9. Sulfinpyrazone
  4. Management
    1. Discontinue offending agent
  5. Course
    1. Expect recovery in 7-10 days
    2. Medications
      1. Sympathetic blockers

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