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Myelofibrosis
- Pathophysiology
- Normal Bone Marrow replaced by fibrotic material
- Symptoms and Signs
- Weight loss
- Excessive Bleeding from skin and mucous membranes
- Diagnosis
- Bone Marrow Biopsy: Dry tap
Myelofibrosis (C0026987) | |
|---|---|
| Definition (MSH) | Replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another, unrelated condition. (Dorland, 27th ed) |
| Definition (CSP) | replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition. |
| Definition (NCI) | A disorder in which the bone marrow is replaced by fibrous tissue. |
| Definition (NCI) | A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003 |
| Concepts | Neoplastic Process (T191) |
| ICD9 | 289.83, 289.83 |
| MSH | D009191 |
| English | Bone Marrow Fibroses, Bone Marrow Fibrosis, MF - Myelofibrosis, MOS, Myelofibroses, Myelofibrosis, Myeloscleroses, MYELOSCLEROSIS |
| Spanish | esclerosis de la medula osea, fibrosis de la medula osea, mielofibrosis, mielosclerosis |
| Parent Concepts | Bone Marrow Diseases (C0005956), Bone marrow depression (C0151773), marrow cells decreased (C0549541), Other specified disorders of blood or blood-forming organ (C0029768), Myeloproliferative disease (C0027022), Fibrosis (C0016059), Reason not stated concept (C1276325) |
| Sources | COSTAR, CSP, CST, DXP, ICD9CM, LCH, MSH, MTH, MTHICD9, NCI, NDFRT, PDQ, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
