Hematology and Oncology Book

http://www.fpnotebook.com/

Non-Hodgkin's Lymphoma

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  1. See Also
    1. Lymphoma
  2. Epidemiology
    1. Most common of solid hematologic malignancies
    2. Incidence: 40,000 new cases/year in United States
  3. Symptoms and Signs (differentiate from Hodgkin's)
    1. Presence of Lymphadenopathy draining Waldeyer's ring
      1. Hodgkin's Lymphoma involves Supraclavicular nodes
    2. Epitrochlear lymph nodes
    3. Mediastinal, abdominal and extranodal involvement
      1. Common at presentation
    4. Chest Pain (suggests lung involvement)
    5. Systemic symptoms more common in Hodgkin's
  4. Pathology (Lymph node histology)
    1. Diffuse small cleaved cell
    2. Poorly differentiated Lymphocytes
  5. Staging
    1. Similar, but not identical to Hodgkin's Lymphoma
  6. Management
    1. Combination Chemotherapy and Radiation Therapy
    2. Monoclonal Antibody in certain cases
      1. Rituxan binds antigen on mature B Cells

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