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Lymphoma

Pathophysiology
1. Cell neoplasia residing in lymphoid tissue
2. Reticuloendothelial organ infiltration
Types
1. Hodgkin's Lymphoma
  1. Localized disease with contiguous nodal spread
  2. Mediastinal involvement
  3. Curability >75%
  4. Systemic Symptoms (Fever, Night Sweats, weight loss)
2. Non-Hodgkin's Lymphoma
  1. Non-contiguous nodal spread
  2. Extranodal involvement
  3. Abdominal and Bone Marrow involvement
  4. Curability <25%
Risk Factors
1. Inherited Immunodeficiency Disease
  1. Klinefelter's Syndrome
  2. Chediak-Higashi Syndrome
  3. Ataxia telangiectasia syndrome
  4. Wiskott-Aldrich Syndrome
  5. Common variable Immunodeficiency disease
2. Acquired Immunodeficiency
  1. Iatrogenic immunosuppression
  2. Acquired Immunodeficiency Syndrome
  3. Acquired hypogammaglobulinemia
3. Autoimmune Disease
  1. Sjogren's Syndrome
  2. Nontropical sprue
  3. Rheumatoid Arthritis
  4. Systemic Lupus Erythematosus
4. Chemical or drug exposure
  1. Phenytoin (Dilantin)
  2. Radiation Therapy
  3. Chemotherapy
5. Viral Association
  1. Epstein-Barr Virus
  2. Human T-Cell Leukemia Virus

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This page was written by Scott Moses, MD, and was last revised 1/26/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 5.0.