Hematology and Oncology Book

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Leukemia

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  1. Epidemiology
    1. Incidence: 13 per 100,000 people per year
    2. Higher Incidence in men
    3. Age distribution
      1. All Ages
        1. Acute Myelogenous Leukemia (AML)
      2. Young
        1. Acute Lymphocytic Leukemia (ALL)
      3. Elderly
        1. Chronic Lymphocytic Leukemia
        2. Hairy Cell Leukemia
  2. Types
    1. Myeloid Leukemia (Bone Marrow)
      1. Acute Myelogenous Leukemia (AML)
      2. Chronic Myelogenous Leukemia (CML)
    2. Lymphoid Leukemia
      1. Acute Lymphocytic Leukemia (ALL)
      2. Chronic Lymphocytic Leukemia (CLL)
      3. Hairy-Cell Leukemia
  3. Pathophysiology
    1. Malignant neoplasm of hematopoietic origin
    2. Origins
      1. Myeloid (Bone Marrow)
      2. Lymphoid
    3. Acute (Proliferating cell fails to mature past blast)
      1. AML: Immature clonal myeloid Cells (Myeloblast)
      2. ALL: Immature clonal lymphoid Cells (Lymphoblast)
  4. Predisposing Factors
    1. Idiopathic
    2. Human T-Cell Leukemia Virus (HTLV-1)
    3. Congenital syndrome
      1. Down's Syndrome
      2. Bloom's Syndrome
      3. Klinefelter's Syndrome
      4. Fanconi's Syndrome
      5. Wiskott-Aldrich Syndrome
    4. Environmental Factors
      1. Ionizing Radiation exposure (risk of CML, AML, ALL)
      2. Chemical exposure (risk of AML)
        1. Aromatic hydrocarbons (e.g. Benzene)
        2. Alkylating Agents
        3. Chemotherapeutic drugs

Other specified leukemia (disorder) (C0029812)

ConceptsNeoplastic Process (T191)
ICD9207, 207.8
EnglishOther specified leukaemia, Other specified leukemia
Spanishotra leucemia especificada
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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