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Total Iron Binding CapacityAka: TIBC

Measurement
1. Transferrin carries 2 iron atoms per molecule
2. Transferrin is normally 30% bound to iron
3. TIBC reflects a measurement of serum Transferrin
  1. Measured by saturating all available binding sites
Normal
1. Range: 250-460 ug/dl
Increased TIBC
1. Iron Deficiency Anemia
2. Third trimester Pregnancy
3. Polycythemia Vera
Decreased TIBC
1. Anemia of Chronic Disease
2. Hemolytic Anemia
3. Hemochromatosis
4. Chronic Liver Disease or Cirrhosis
5. Hypoproteinemia
6. Malnutrition
7. Pernicious Anemia
8. Sickle Cell Anemia

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This page was written by Scott Moses, MD, and was last revised 1/26/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 5.0.