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Red Cell Distribution WidthAka: RDW

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  1. Indications: Anemia Evaluation
    1. Iron Deficiency Anemia from other Microcytic Anemias
    2. May increase before MCV becomes abnormal
  2. Definition
    1. Measures size variability of Red Blood Cell population
  3. Normal
    1. Range: 11.5-14.5%
  4. Normal Red Cell Distribution Width (RDW)
    1. Mean Corpuscular Volume (MCV) Increased
      1. Aplastic Anemia
      2. Pre-Leukemia
    2. Mean Corpuscular Volume (MCV) Normal
      1. Anemia of Chronic Disease
      2. Acute blood loss
      3. Hemolysis
      4. Chronic Lymphocytic Leukemia (CLL)
      5. Chronic Myelogenous Leukemia (CML)
      6. Hemoglobinopathy
      7. Normal variant
    3. Mean Corpuscular Volume (MCV) Decreased
      1. Anemia of Chronic Disease
      2. Thalassemia (heterozygous)
  5. Increased Red Cell Distribution Width (RDW)
    1. Mean Corpuscular Volume (MCV) Increased
      1. Vitamin B12 Deficiency
      2. Folate Deficiency
      3. Immune Hemolytic Anemia
      4. Liver disease
    2. Mean Corpuscular Volume (MCV) Normal
      1. RDW increases before MCV becomes abnormal
        1. Early Iron Deficiency Anemia
        2. Early Vitamin B12 Deficiency
        3. Early Folate Deficiency
      2. Anemic globinopathy
    3. Mean Corpuscular Volume (MCV) Decreased
      1. Iron Deficiency Anemia
      2. RBC fragmentation
      3. HbH
      4. Thalassemia intermedia

Red cell distribution width determination (C0427460)

Definition (NCI)An index of the variation in the size of the red cells and can be used to detect subtle degress of anisocytosis. It is computed directly from the RBC histogram and is calculated as a standard statictical value, the coefficient of variation of the red cell volume ditribution (ratio of standard deviation and mean copuscular volume).
Definition (NCI)A value derived from mean corpuscular volume and the standard deviation of the red blood cell volume in a whole blood specimen.
ConceptsLaboratory Procedure (T059)
EnglishErythrocyte distribution width, Erythrocyte Distribution Width Measurement, Erythrocytes Distribution Width, RDW, RDW - Red blood cell distribution width, RDW determination, Red blood cell distribution width, Red cell distribution width determination
Spanishdeterminacion de la eritrosedimentacion, determinacion de la ESD, determinacion de la velocidad de sedimentacion globular, determinacion de la VSG
Parent ConceptsHematologic Technique (C1708343), Red blood cell indices determination (C0200657), Duplicate concept (C1274013)
SourcesLNC, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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