Hematology and Oncology Book

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Partial Thromboplastin TimeAka: PTT

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  1. Normal
    1. Range: 25-41 sec
  2. Increased
    1. Heparin
    2. Warfarin (Coumadin)
    3. Thrombolytics
    4. Clotting Factor deficiency
      1. Factor I Deficiency
      2. Factor II Deficiency
      3. Factor V Deficiency
      4. Factor VIII Deficiency (Hemophilia A)
      5. Factor IX Deficiency (Hemophilia B)
      6. Factor X Deficiency
      7. Factor XI Deficiency
      8. Factor XII Deficiency
    5. Liver disease
    6. Vitamin K Deficiency
    7. Disseminated Intravascular Coagulation (DIC)
    8. Circulating anticoagulants or specific factor inhibitor
      1. Penicillin reaction
      2. Rheumatoid Factor

Activated Partial Thromboplastin Time measurement (C0030605)

Definition (MSH)The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Definition (NCI)A measurement of the length of time that it takes for clotting to occur when reagents are added to a plasma specimen. The test is partial due to the absence of tissue factor (Factor III) from the reaction mixture.
Definition (NCI)This is a measurement of the intrinsic pathway of coagulation. Significant deficiency in factors II, V, VIII, IX, X, XI, XII or anticoagulants will prolong PTT. (BioTech Life Science Dictionary)
ConceptsLaboratory Procedure (T059)
EnglishActivated Partial Thromboplastin Time, Activated Partial Thromboplastin Time measurement, APTT, Partial Thromboplastin Time, Partial thromboplastin time activated, partial thromboplastin time: PTT, PTT, PTT assay
Spanishactivación de tiempo parcial de tromboplastina, activacion de tiempo parcial de tromboplastina
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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