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Neutropenia CausesAka: Agranulocytosis Causes

See Also
Causes: Decreased Neutrophil Production
1. Marrow Infiltration
  1. Leukemia
  2. Myelodysplastic syndrome
  3. Myelofibrosis (tumor invasion)
  4. Granulomatous infiltration (e.g. Tuberculosis)
2. Marrow Injury
  1. Radiation
  2. Aplastic Anemia
  3. Paroxysmal Nocturnal Hemoglobinuria
  4. Medications
    1. See Drug-Induced Agranulocytosis
  5. Infection
    1. See Infectious Causes of Neutropenia
Causes: Increased Neutrophil Destruction
1. Severe Sepsis (increased consumption)
2. Antineutrophil Antibody
3. Hypersplenism (Splenic trapping)
4. Felty's Syndrome
5. Systemic Lupus Erythematosus
6. Chediak-Higashi Syndrome (rare autosomal recessive)
7. Medications
  1. Phenylbutazone
  2. Phenothiazine
Causes: Lower Clinical Significance
1. Pseudoneutropenia (based on automated count)
2. Maturation Defect
  1. Vitamin B12 Deficiency
  2. Folic Acid deficiency
3. Margination (distribution)
  1. Bacterial infection (endotoxin)
  2. Hemodialysis
  3. Cardiopulmonary bypass

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 5/10/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.