Hematology and Oncology Book

http://www.fpnotebook.com/

LeukocytosisAka: Leukemoid Reaction, Reactive Leukocytosis

Advertisement

  1. See Also
    1. Complete Blood Count
    2. White Blood Cell Count
  2. Definition
    1. White Blood Cell Count over 10,000/mm3
  3. Causes: Cell line specific causes
    1. Neutrophilia (most common cause)
    2. Lymphocytosis
    3. Monocytosis
    4. Eosinophilia (rarely causes leukocytosis)
  4. Causes: Benign Syndromes
    1. Leukemoid Reaction
      1. WBC Count exceeds 50,000
      2. Cause not involving Bone Marrow
      3. Usually due to non-malignant cause
    2. Reactive Leukocytosis
      1. Fever
      2. Focal infectious signs
      3. Normal Platelet Count and Hemoglobin
  5. Causes: Malignancy
    1. Acute Leukemia
      1. Thrombocytopenia
      2. Peripheral Smear with many immature cells (blasts)
      3. Marrow hypercellular with >30% blast cells
      4. Hyperuricemia
    2. Chronic Leukemia
      1. Normal Platelet Count and Hemoglobin
  6. Red flag signs of Bone Marrow disease
    1. Lab abnormalities
      1. Anemia
      2. Thrombocytopenia
      3. Severe Leukocytosis
        1. WBC Count >30,000/mm3 suggests marrow abnormality
        2. WBC Count >100,000/mm3 (urgent hematology consult)
    2. Recent History
      1. Serious Infection
      2. Immunosuppression
      3. Weight loss
    3. Physical Findings
      1. Lymphadenopathy
      2. Splenomegaly
      3. Hepatomegaly
      4. Bleeding, Ecchymosis, or Petechiae
      5. Lethargy
  7. Evaluation
    1. Complete Blood Count with Platelets
    2. Bone Marrow Aspiration (critical in Acute Leukemia)
    3. Labs in Acute Leukemia
      1. Serum and Urine Lysozyme level
      2. Uric Acid
      3. Disseminated Intravascular Coagulation (DIC) Labs
        1. ProTime
        2. Partial Thromboplastin Time
        3. Fibrinogen
        4. Fibrin Degradation Products
  8. References
    1. Saiki in Friedman (1991) Medical Diagnosis, p. 227
    2. Abramson (2000) Am Fam Physician 62(9):2053

Leukemoid Reaction (C0023501)

Definition (MSH)A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone. (Dorland, 27th ed)
ConceptsDisease or Syndrome (T047)
ICD9288.62
EnglishLEUKAEMOID REACTION, Leukemoid Reaction, Leukemoid Reactions, REACTION LEUKEMOID
Spanishreacción leucemoide, reaccion leucemoide
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Leukocytosis (C0023518)

Definition (MSH)A transient increase in the number of leukocytes in a body fluid.
Definition (CSP)transient increase in the number of leukocytes in a body fluid.
ConceptsPathologic Function (T046)
ICD9288.60
EnglishIncreased blood leucocyte number, Increased blood leukocyte number, Leucocytosis, Leukocytoses, Leukocytosis
Spanishaumento del número de leucocitos en sangre, aumento del numero de leucocitos en sangre, leucocitosis
CreditsDerived from the NIH UMLS (Unified Medical Language System)



Navigation Tree