I. See Also

II. Characteristics

  1. Function: Allergic Response
    1. Similar Mechanism of action to mast cells
    2. Related to delayed hypersensitivity response
    3. Triggered by IgE binding to antigen
    4. Releases inflammatory mediators
      1. Preformed mediators (e.g. Histamine, Bradykinin)
      2. New Mediators (e.g. Prostaglandins, Leukotrienes)
      3. Chemotactic factors attract Neutrophil, Eosinophil
  2. Morphology on Blood Smear
    1. Granulocyte cytoplasm stains darkly with Wright Stain
    2. Two lobed nucleus

III. Normal Levels

  1. Range: 0.4-1.0% (Least common Leukocyte)

IV. Increased Basophils (Basophilia)

  1. Viral infections (e.g. Varicella)
  2. Hodgkin's Lymphoma
  3. Hemolytic Anemia
  4. Following splenectomy
  5. Myeloproliferative disease
    1. Chronic Myelogenous Leukemia
    2. Polycythemia Vera
    3. Myelofibrosis
  6. Inflammatory processes
    1. Inflammatory Bowel Disease
    2. Chronic dermatitis
    3. Asthma
    4. Chronic Sinusitis
  7. Endocrine causes
    1. Hypothyroidism
    2. Increased Estrogen

V. Decreased Basophils

Images: Related links to external sites (from Google)

Ontology: Basophils (C0004827)

Definition (NCI) eactions and asthma. A basophil is a type of white blood cell and a type of granulocyte.
Definition (MSH) Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Definition (CSP) granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes; contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation.
Concepts Cell (T025)
MSH D001491
SnomedCT 30061004
English Basophils, basophil, Blood basophil, Marrow basophil, Basophil, segmented, basophilic granulocyte, basophilic leukocyte, Basophil leukocyte, basophils, Basophil, Basophil, segmented (cell)
Spanish basófilo, segmentado, basófilo, segmentado (célula), basófilo, granulocito basófilo, Basofilos, Basófilos
French Polynucléaires basophiles, Granulocyte basophile, PNB (Polynucléaire Basophile), Basophiles, Polynucléaire basophile, Granulocytes basophiles
Swedish Basofiler
Czech bazofily, granulocyty bazofilní
Finnish Basofiilit
Latvian Bazofili
Polish Bazofile, Granulocyty zasadochłonne
German Basophile Leukozyten, Basophile
Italian Basofili
Dutch Basofiel, Basofiele leukocyt, Basofielen
Portuguese Basófilos

Ontology: Blood basophil count (lab test) (C0200641)

Concepts Laboratory Procedure (T059)
SnomedCT 165526006, 142941000, 142937004, 165529004, 42351005
English Basophils, Blood cell count, basophil, Basophil count NOS, blood basophil count, blood basophil count (lab test), Basophil count NOS (procedure), basophil count, Blood basophil count (lab test), basophils count, Basophil count, Basophil count (procedure), Basophil count [dup] (procedure)
Italian Conta basofila, Basofili
Dutch basofielen, basofielentelling
French Basophiles, Numération des basophiles
German basophile Granulozyten, Basophilenzahl
Portuguese Basófilos, Número de basófilos
Spanish Basófilos, Basophil count, Basophil count [dup] (procedure), Basophil count NOS, recuento de basófilos (procedimiento), recuento de basófilos, SAI (procedimiento), recuento de basófilos, SAI, recuento de basófilos, Recuento de basófilos
Japanese 好塩基球, 好塩基球数, コウエンキキュウスウ, コウエンキキュウ
Czech Bazofily, Počet bazofilů
Hungarian Bazofilek, Bazofil szám

Ontology: Basophilia (C0702266)

Concepts Finding (T033)
ICD9 288.65
ICD10 D72.824
SnomedCT 142939001, 65209002
English BASOPHILIA, basophilia, basophilia (diagnosis), basophilic leukocytosis, basophilia disorder, basophilia test result, Basophilic leukocytosis, Basophilia (finding), Basophilic leucocytosis, Basophilia
Italian Basofilia
Japanese 好塩基球増加症, コウエンキキュウゾウカショウ
Spanish Basophilia, BASOFILIA, basofilia (hallazgo), basofilia, leucocitosis con basofilia, Basofilia
Portuguese BASOFILIA, Basofilia
French BASOPHILIE, Basophilie
German BASOPHILIE, Basophilie
Czech Bazofilie
Hungarian basophilia
Dutch basofilie