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Basophil CountAka: Basophil, Basophilia

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  1. See Also
    1. Complete Blood Count
  2. Characteristics
    1. Function: Allergic Response
      1. Similar mechanism of action to mast cells
      2. Related to delayed hypersensitivity response
      3. Triggered by IgE binding to antigen
      4. Releases inflammatory mediators
        1. Preformed mediators (e.g. Histamine, Bradykinin)
        2. New Mediators (e.g. Prostaglandins, Leukotrienes)
        3. Chemotactic factors attract Neutrophil, Eosinophil
    2. Morphology on Blood Smear
      1. Granulocyte cytoplasm stains darkly with Wright Stain
      2. Two lobed nucleus
  3. Normal Levels
    1. Range: 0.4-1.0% (Least common Leukocyte)
  4. Increased Basophils (Basophilia)
    1. Viral infections (e.g. Varicella)
    2. Hodgkin's Lymphoma
    3. Hemolytic Anemia
    4. Following splenectomy
    5. Myeloproliferative disease
      1. Chronic Myelogenous Leukemia
      2. Polycythemia Vera
      3. Myelofibrosis
    6. Inflammatory processes
      1. Inflammatory Bowel Disease
      2. Chronic dermatitis
      3. Asthma
      4. Chronic Sinusitis
    7. Endocrine causes
      1. Hypothyroidism
      2. Increased Estrogen
  5. Decreased Basophils
    1. Stress
    2. Hypersensitivity Reaction
    3. Corticosteroids
    4. Pregnancy
    5. Hyperthyroidism

Basophils (C0004827)

Definition (MSH)Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Definition (CSP)granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes; contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation.
Definition (NCI)A type of granular leukocyte with granules that are easily stained by basic stains.
ConceptsCell (T025)
MSHD001491
EnglishBasophil, basophilic granulocyte, basophilic leukocyte, Basophils
Spanishbasofilo, granulocito basofilo
Parent Conceptsgranulocyte (C0018183), Body part (C0229962), Leukocytes (C0023516), Leukocyte - Myelocyte (Granulocyte) (MMHCC) (C1522160), neutrophil (C0027950), Basophilic granulocytic cell (C1268009)
SourcesAOD, CSP, HL7V2.5, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Basophil count (C0200641)

ConceptsLaboratory Procedure (T059)
EnglishBasophil count
Spanishrecuento de basofilos
Parent ConceptsBlood Cell Count (C0005771), White Blood Cell Count procedure (C0023508), Basophil count (C0200641), Duplicate concept (C1274013)
SourcesMTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Basophilia (C0702266)

ConceptsFinding (T033)
ICD9288.65
EnglishBasophilia, Basophilic leucocytosis, Basophilic leukocytosis
Spanishbasofilia, leucocitosis con basofilia
Parent ConceptsWhite blood cell abnormality (C0152009), Erythrocyte Abnormalities, General and NEC (C0549529), White Blood Cell Count Increased (C0750426), Abnormal Hematology Test Result (C1332130), White blood cell count laboratory result (C0427512), Abnormally increased cellular element of blood (C1263974), Raised hematology findings (C0586730), Duplicate concept (C1274013)
SourcesCST, DXP, ICD9CM, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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