Hematology and Oncology Book

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Antithrombin III

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  1. Indications
    1. Hypercoagulable state evaluation
  2. Normal
    1. Activity: 80-120% of normal activity
    2. Level: 17-30 mg/dl
  3. Increased
    1. Warfarin (Coumadin)
    2. Post-Myocardial Infarction
  4. Decreased
    1. Hereditary Antithrombin III deficiency
    2. Disseminated Intravascular Coagulation
    3. Pulmonary Embolus
    4. Cirrhosis
    5. Thrombolysis
    6. Chronic liver failure
    7. Post-surgery
    8. Nephrotic Syndrome
    9. Sepsis
    10. Medications
      1. Intravenous Heparin use longer than 3 days
      2. Oral Contraceptive Use

Antithrombin III (C0003438)

Definition (MSH)A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes; it was formerly called Antithrombin II (AT II) which has now been shown to be identical to AT III; ANTITHROMBIN III DEFICIENCY, hereditary or acquired, results in thromboembolism. It is a member of the serpin superfamily. Some authors use the term antithrombin to refer to antithrombin III.
Definition (CSP)blood glycoprotein which inhibits thrombin and other blood coagulation factors; important to maintenance of normal blood fluidity.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Biologically Active Substance (T123)
EnglishAntithrombin, Antithrombin II, Antithrombin III, Antithrombin III preparation, Antithrombin III product, AT3, FACTOR XA INHIB, Factor Xa Inhibitor, Heparin Co Factor I, Heparin Cofactor I
Spanishantitrombina II, antitrombina III, preparado con antitrombina III, preparado de antitrombina III
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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