Hematology and Oncology Book

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Priapism in Sickle Cell Anemia

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  1. See Also
    1. Sickle Cell Anemia
    2. Priapism
  2. Course
    1. Resolves spontaneously
    2. May occur frequently
  3. Management
    1. Medications
      1. Nifedipine 10 mg (in repeated doses)
      2. Nitroglycerin patch (0.2 - 0.4 mg/hour)
        1. Applied at bedtime may prevent nighttime attacks
    2. Admission Criteria
      1. Priapism persists >6 hours
    3. Urology consultation indications
      1. Priapism refractory to medical management >24 hours
      2. Corpora spongiosa and cavernosa Shunt
        1. Placed through glans penis
        2. Often effective (may need repeat)
        3. Does not interfere with subsequent Erection
  4. Complications
    1. Repeated Priapism results in
      1. Thickening and gross enlargement of the penis
      2. Penis may remain semi-erect
    2. Impotence
      1. Penile Implants

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