Hematology and Oncology Book

http://www.fpnotebook.com/

Intrinsic Clotting Pathway

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  1. Pathophysiology
    1. Initiated by negatively charged surface
  2. Pathway
    1. Factor XII converted to Factor XIIa
      1. Cofactors
        1. PK
        2. HMWK
      2. Inhibitors
        1. Heparin
        2. Antithrombin III
    2. Factor XI converted to Factor XIa
    3. Factor IX converted to Factor IXa
      1. Cofactors:
        1. Factor VIII
        2. von Willebrand's factor (vWF) carries Factor VIII
      2. Inhibitors
        1. Protein C
        2. Protein S
    4. Factor X converted to Factor Xa
    5. Joins Common Clotting Pathway

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