Hematology and Oncology Book

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Clotting PathwayAka: Coagulation Pathway, Clotting Factor, Coagulation Factor

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  1. Pathways
    1. Initiators of the clotting cascade
      1. Intrinsic Clotting Pathway
        1. Initiated by Negatively charged surface
      2. Extrinsic Clotting Pathway
        1. Initiated by disrupted cell membranes
    2. Common Clotting Pathway follows above initiators
      1. Antagonized by Clotting Pathway Inhibition
  2. Labs
    1. Partial Thromboplastin Time (PTT)
      1. Measures intrinsic pathway
      2. Prolonged by
        1. Factor VIII Deficiency (Hemophilia A)
        2. Factor IX Deficiency (Hemophilia B)
    2. Prothrombin Time (PT)
      1. Measures extrinsic pathway
    3. Affecting both ProTime and Partial Thromboplastin Time
      1. Factor X
      2. Factor V
      3. Prothrombin
      4. Fibrinogen
    4. Thrombin Time
      1. Measures only common pathway
  3. Medications for Anticoagulation
    1. Warfarin (Coumadin)
    2. Heparin
  4. Coagulation disorder etiologies
    1. Hypercoagulable State
      1. Protein C Deficiency
      2. Protein S Deficiency
      3. Antithrombin III deficiency
    2. Bleeding Diathesis
      1. Factor VIII Deficiency (Hemophilia A)
      2. Factor IX Deficiency (Hemophilia B)
      3. Von Willebrand's Disease

Blood Coagulation Factor (C0005789)

Definition (MSH)Endogenous substances, usually proteins, that are involved in the blood coagulation process.
Definition (CSP)class of endogenous substances, usually proteins, that are involved in the blood coagulation process.
Definition (NCI)Factors in the blood that are essential for blood coagulation. The absence or mutation of these factors can lead to hemophilia and blood clotting disorders.
ConceptsAmino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123)
EnglishBlood clotting factor, BLOOD COAG FACTOR, BLOOD COAG FACTORS, Blood Coagulation Factor, Blood Coagulation Factors, Clotting Factor, COAG FACTOR, COAG FACTOR BLOOD, COAG FACTORS, COAG FACTORS BLOOD, Coagulation Factor, Coagulation Factors, FACTOR COAG, FACTORS COAG
Spanishfactor de coagulacion, factor de la coagulacion de la sangre, factor de la coagulacion sanguinea
Parent ConceptsSerum Proteins (C0036825), Blood Proteins (C0005832), Biological Factors (C0005515), Binding Protein (C0242210), Hemostasis related substance (C1292271), Blood derivative (C1629497)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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