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Protein C DeficiencyAka: Protein S Deficiency
- Pathophysiology
- Protein C neutralizes factors V and VIII
- Deficiency inherited Autosomal Dominant
- Venous thrombosis occurs if functional levels <50%
- Protein S is cofactor for Protein C
- Venous thrombosis occurs if functional levels <60%
- Protein C and Protein S are both Vitamin K dependent
- Complications
- Warfarin induced skin necrosis
- Protein C (short half life)
- Microvascular thrombi to skin
- Administer Heparin before Warfarin
- Eliminates risk of this complication
- Purpura fulminans
- Infants homozygous for Protein C deficiency
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