Hematology and Oncology Book

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Hyperviscosity Syndrome

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  1. Causes
    1. Leukemia
    2. Multiple Myeloma
    3. Waldenstrom's Macroglobulinemia
      1. Hyperviscosity uncommon
  2. Pathophysiology
    1. Increased circulating serum Immunoglobulins
    2. Immunoglobulins coat Red Blood Cells
    3. Results in increased viscosity and sludging
    4. End result is end organ decreased perfusion
  3. Signs
    1. Spontaneous bleeding
    2. Peripheral Neuropathy
    3. Vision change
      1. Hemorrhagic retinal veins (appear as sausages)
  4. Labs
    1. Serum viscosity: >5 cP
  5. Management
    1. Plasmaphoresis
    2. Chemotherapy
  6. References
    1. Higdon (2006) Am Fam Physician 74:1873

Hyperviscosity syndrome (C0221030)

Definition (CSP)any syndrome associated with increased viscosity of the blood; in syndrome of serum hyperviscosity there is spontaneous bleeding and neurologic and ocular disorders; syndromes of polycythemic hyperviscosity is marked by retarded blood flow, organ congestion, reduced capillary perfusion, and increased cardiac effort; syndromes of sclerocythemic hyperviscosity comprise those in which the deformability of erythrocytes is impaired, as in sickle cell anemia.
ConceptsDisease or Syndrome (T047)
EnglishHyperviscosity syndrome, Reimann's syndrome
Spanishsindrome de hiperviscosidad, sindrome de Reimann
Parent ConceptsHematological Disease (C0018939), Syndrome (C0039082), Disease (C0012634)
SourcesCSP, DXP, QMR, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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