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Hyperviscosity Syndrome
- Causes
- Leukemia
- Multiple Myeloma
- Waldenstrom's Macroglobulinemia
- Hyperviscosity uncommon
- Pathophysiology
- Increased circulating serum Immunoglobulins
- Immunoglobulins coat Red Blood Cells
- Results in increased viscosity and sludging
- End result is end organ decreased perfusion
- Signs
- Spontaneous bleeding
- Peripheral Neuropathy
- Vision change
- Hemorrhagic retinal veins (appear as sausages)
- Labs
- Serum viscosity: >5 cP
- Management
- Plasmaphoresis
- Chemotherapy
- References
Hyperviscosity syndrome (C0221030) | |
|---|---|
| Definition (CSP) | any syndrome associated with increased viscosity of the blood; in syndrome of serum hyperviscosity there is spontaneous bleeding and neurologic and ocular disorders; syndromes of polycythemic hyperviscosity is marked by retarded blood flow, organ congestion, reduced capillary perfusion, and increased cardiac effort; syndromes of sclerocythemic hyperviscosity comprise those in which the deformability of erythrocytes is impaired, as in sickle cell anemia. |
| Concepts | Disease or Syndrome (T047) |
| English | Hyperviscosity syndrome, Reimann's syndrome |
| Spanish | sindrome de hiperviscosidad, sindrome de Reimann |
| Parent Concepts | Hematological Disease (C0018939), Syndrome (C0039082), Disease (C0012634) |
| Sources | CSP, DXP, QMR, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
