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Factor V LeidenAka: Factor 5 Leiden, Activated Protein C resistance, APC Resistance
- Epidemiology
- Responsible for 20-50% of Hypercoagulable patients
- Incidence of Autosomal dominant genetic defect
- Europeans: 15%
- North America: 3-5%
- Risks
- Heterozygote: 5-10 times the risk of thrombosis
- Homozygote: 50-100 times the risk of thrombosis
- Pathophysiology
- Factor V is a cofactor for Factor X
- Defect prevents Factor V degradation by Protein C
- Labs
- Activated Protein C (APC) resistance
- Can not be anticoagulated when this lab run
- PCR for Factor V Leiden
- Responsible for 95% of APC resistance
- Does NOT require that patient be off Anticoagulation
- Complications
- Deep Vein Thrombosis
- Pulmonary Embolism
- Myocardial Infarction
Activated Protein C Resistance (C0600433)
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| Definition (MSH) | A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. |
| Concepts | Disease or Syndrome (T047)
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| ICD9 | 289.81 |
| English | Activated Protein C Resistance, APC Resistance, Resistance to activated protein C due to Factor V Leiden, Resistance to activated protein C due to Factor V R506Q |
| Spanish | resistencia a la proteina C activada debido al Factor V de Leiden |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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