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Antithrombin III deficiency

Pathophysiology
1. Antithrombin III normally inhibits
  1. Factor IXa
  2. Factor Xa
  3. Factor XIa
  4. Factor XIIa
  5. Thrombin
2. Enhanced by Heparin
Epidemiology
1. Heterozygotes have 25-50% ATIII functional levels
2. First episode of thrombosis occurs ages 10-30 years
Complications
1. Venous Thromboembolism
Labs
1. Functional level Antithrombin III

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.

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Antithrombin III deficiency

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