Hematology and Oncology Book

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Sideroblastic Anemia

Aka: Sideroblastic Anemia, Pearson Syndrome
  1. See Also
    1. Microcytic Anemia
  2. Pathophysiology
    1. Defective heme metabolism
  3. Causes
    1. Toxin Exposure
      1. Alcohol Abuse
      2. Lead exposure
      3. Isoniazid
      4. Chloramphenicol
    2. Neoplasm or inflammatory disease
      1. Carcinoma
      2. Leukemia
      3. Lymphoma
      4. Rheumatoid Arthritis
    3. X-Linked recessive Sideroblastic Anemia
    4. Pearson Syndrome
      1. Vacuolation of marrow precursor cells
      2. Exocrine pancreatic dysfunction
  4. Labs
    1. Complete Blood Count
      1. See Hemoglobin Cutoffs for Anemia
      2. See Hematocrit Cutoffs for Anemia
      3. Mean Corpuscular Volume (MCV) <80 fl
        1. See MCV Cutoffs for Microcytic Anemia
        2. MCV cutoff varies by age and per reference
    2. Serum Iron increased
    3. Peripheral Smear
      1. Hypochromic Microcytic Anemia
    4. Bone Marrow Aspirate
      1. Ringed Sideroblasts
  5. Management
    1. Remove offending exposure
    2. Pyridoxine (variable efficacy)

Pearson's marrow-pancreas syndrome (C0342773)

Concepts Disease or Syndrome (T047)
MSH C536314
SnomedCT 237985009
Italian Sindrome di Pearson
Japanese ピアソン症候群, ﾋﾟｱｿﾝｼｮｳｺｳｸﾞﾝ
English PEARSON MARROW-PANCREAS SYNDROME, SIDEROBLASTIC ANEMIA WITH MARROW CELL VACUOLIZATION AND EXOCRINE PANCREATIC DYSFUNCTION, Pearson syndrome (diagnosis), Pearson syndrome, Sideroblastic anemia with marrow cell vacuolization and exocrine pancreatic dysfunction, Pearson's marrow-pancreas syndrome, Pearson's syndrome, Pearson's syndrome (disorder), Pearson marrow-pancreas syndrome
Czech Pearsonův syndrom
Hungarian Pearson-syndroma
Spanish síndrome de Pearson (trastorno), síndrome de Pearson, Síndrome de Pearson
Portuguese Síndrome de Pearson
Dutch Pearson-syndroom
French Syndrome de Pearson
German Pearson-Syndrom
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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