Hematology and Oncology Book

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Idiopathic Thrombocytopenic Purpura

Aka: Idiopathic Thrombocytopenic Purpura, Immune Thrombocytopenic Purpura, ITP
  1. See Also
    1. Thrombocytopenia
    2. Drug induced Thrombocytopenia
  2. Epidemiology
    1. Most common Thrombocytopenia cause in children
    2. Peak onset between ages 2 to 4 years
  3. Pathophysiology
    1. IgG Antibody develops against platelet membrane antigen
    2. Acute Idiopathic Thrombocytopenic Purpura
      1. Acute onset follows Viral Exanthem or viral Infection
      2. Occurs in otherwise healthy patients
    3. Chronic Idiopathic Thrombocytopenic Purpura
      1. Insidious onset in patient with immune disorder
      2. More common onset in teenage girls
  4. Signs and Symptoms
    1. Purpura
    2. Mild Splenomegaly in 5 to 10% of cases
    3. Absent signs
      1. No fever, lethargy, pallor or weight loss
      2. No bone or joint pain
      3. No Lymphadenopathy
      4. No Hepatomegaly
  5. Labs
    1. Platelet Count drops rapidly
  6. Management
    1. Corticosteroids
    2. Splenectomy in refractory cases
      1. Safe and effective
      2. May be preferred in younger patients
      3. Gadenstatter (2002) Am J Surg 184:606-10
  7. Course: Acute Idiopathic Thrombocytopenic Purpura
    1. Recovery within 6 to 12 months for 80-90% of children
    2. Most cases resolve within weeks
  8. References
    1. Blanchette (2000) Semin Hematol 37(3):299-314
    2. Bolton-Maggs (2000) Arch Dis Child 83(3):220-2
    3. George (1996) Blood 88:3-40
    4. Souid (1995) Clin Pediatr 34:487-94

Purpura, Thrombocytopenic, Idiopathic (C0043117)

Definition (NCI) An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.
Definition (CHV) bleeding or bruising tendency due to low platelet level
Definition (CHV) bleeding or bruising tendency due to low platelet level
Definition (CHV) bleeding or bruising tendency due to low platelet level
Definition (CHV) bleeding or bruising tendency due to low platelet level
Definition (NCI) A condition in which platelets (blood cells that cause blood clots to form) are destroyed by the immune system. The low platelet count causes easy bruising and bleeding, which may be seen as purple areas in the skin, mucous membranes, and outer linings of organs.
Definition (MSH) Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Concepts Disease or Syndrome (T047)
MSH D016553
ICD10 D69.3
SnomedCT 191316002, 32273002, 13172003, 154825008, 191315003, 267567001
English Autoimmune Thrombocytopenic Purpura, Autoimmune Thrombocytopenic Purpuras, Disease, Werlhof, Idiopathic Thrombocytopenic Purpura, Idiopathic Thrombocytopenic Purpuras, Purpura, Autoimmune Thrombocytopenic, Purpura, Idiopathic Thrombocytopenic, Purpura, Thrombocytopenic, Autoimmune, Purpura, Thrombocytopenic, Idiopathic, Purpuras, Autoimmune Thrombocytopenic, Purpuras, Idiopathic Thrombocytopenic, Thrombocytopenic Purpura, Autoimmune, Thrombocytopenic Purpura, Idiopathic, Thrombocytopenic Purpuras, Autoimmune, Thrombocytopenic Purpuras, Idiopathic, Werlhof Disease, Werlhof's Disease, Werlhofs Disease, Disease, Werlhof's, PURPURA, THROMBOCYTOPENIC, IDIOPATHIC, WERLHOF DISEASE, ITP, NOS, Idiopathic thrombocytopenic purpura, NOS, Autoimmune thrombocytopen purp, ITP - Idiopat thrombocytop pur, ITP - Idiopathic thrombocytopenic purpura, Idiopath thrombocytopen purpur, Idiopathic purpura, NOS, IDIOPATHIC THROMBOCYTOPENIC PURPURA, Idiopathic thrombocytopenic purpura (ITP), THROMBOCYTOPENIC PURPURA, AUTOIMMUNE, WERLHOF DIS, WERLHOFS DIS, idiopathic thrombocytopenia purpura, itp, Idiopathic purpura (& thrombocytopenic) (disorder), idiopathic thrombocytopenic purpura (diagnosis), ITP (idiopathic thrombocytopenic purpura), idiopathic thrombocytopenic purpura, idiopathic thrombocytopenic purpura (ITP), Thrombocytopenia Due to Platelet Alloimmunization, Idiopathic Thrombocytopenia Purpura, Idiopathic Thrombocytopenia, IMMUNE THROMBOCYTOPENIC PURPURA, AITP, Purpura, Thrombocytopenic, Idiopathic [Disease/Finding], idiopathic purpura, werlhof's disease, immune thrombocytopenic purpura, Werlhof's syndrome, ITP, Idiopathic thrombocytopenic purpura, Werlhof's disease, Autoimmune thrombocytopenic purpura, Idiopathic purpura, Idiopathic thrombocytopenic purpura (disorder), Frank, Werlhof, idiopathic; purpura, purpura; idiopathic, purpura; thrombocytopenic, idiopathic, thrombocytopenic; purpura, idiopathic, Ideopath thrombocytopenic pur, Idiopathic purpura (& thrombocytopenic), ITP - idiopathic thrombocytopenic purpura, Idiopath Thrombocytopenic Purp
Dutch idiopathische purpura, ITP, syndroom van Werlhof, idiopathisch; purpura, purpura; idiopathisch, purpura; trombocytopenisch, idiopathisch, trombocytopenisch; purpura, idiopathisch, idiopathische trombocytopenische purpura, Auto-immune trombocytopenische purpura, Idiopathische trombocytopenische purpura, Idiopathische trombocytopenische purpura (ITP), Purpura, idiopathische trombocytopenische (ITP), Purpura, trombocytopenische auto-immune, Trombocytopenische purpura (ITP), idiopathische, Werlhof, ziekte van
French Purpura idiopathique, PTI, Syndrome de Werlhof, PTI (Purpura Thrombocytopénique Idiopathique), Purpura thrombopénique idiopathique de Werlhof, Purpura thrombopénique idiopathique, Maladie de Werlhof, PTAI, Purpura thrombocytopénique auto-immun, Purpura thrombocytopénique autoimmun, Purpura thrombocytopénique idiopathique, Purpura thrombopénique auto-immun, Purpura thrombopénique autoimmun
German ITP, Werlhofsyndrom, idiopathische Purpura, Purpura idiopathisch thrombozytopenisch, Autoimmun-thrombozytopenische Purpura, Idiopathische thrombozytopenische Purpura, Purpura, thrombozytopenische, Autimmun-, Purpura, thrombozytopenische, idiopathische, Werlhof-Syndrom
Italian Sindrome di Werlhof, Porpora idiopatica, Porpora trombocitopenica autoimmune, Morbo di Werlhof, Porpora trombocitopenica idiopatica
Portuguese Síndrome de Werlhof, Púrpura idiopática, Púrpura trombocitopénica idiopática, Doença de Werlhof, Púrpura Trombocitopênica Auto-Imune, Púrpura Trombocitopênica Idiopática
Spanish Síndrome de Werlhof, Púrpura idiopática, ITP - idiopathic thrombocytopenic purpura, Ideopath thrombocytopenic pur, Idiopathic thrombocytopenic purpura, Idiopathic purpura, ITP - Idiopathic thrombocytopenic purpura, Idiopathic purpura (& thrombocytopenic), PTI, enfermedad de Werlhof, púrpura idiopática, púrpura trombocitopénica idiopática (trastorno), púrpura trombocitopénica idiopática, Púrpura trombocitopénica idiopática, Enfermedad de Werlhof, Púrpura Trombocitopénica Idiopática, Púrpura Trombocitopénica Autoinmune, Purpura Trombocitopenica Autoinmune, Purpura Trombocitopenica Idiopatica
Japanese 特発性紫斑病, ウェルホーフ症候群, ＩＴＰ, ﾄｸﾊﾂｾｲｼﾊﾝﾋﾞｮｳ, ﾄｸﾊﾂｾｲｹｯｼｮｳﾊﾞﾝｹﾞﾝｼｮｳｾｲｼﾊﾝﾋﾞｮｳ, ITP, ｳｪﾙﾎｰﾌｼｮｳｺｳｸﾞﾝ, 紫斑病-特発性血小板減少性, ウェルホーフ紫斑, ウェルホーフ病, ウェルホーフ紫斑病, 特発性血小板減少性紫斑, 特発性血小板減少性紫斑病, 特発血小板減少性紫斑病, 自己免疫性血小板減少性紫斑病, ウェルルホフ病, ヴェルホーフ病, ヴェルルホフ病, 紫斑病-自己免疫性血小板減少性, 紫斑病-血小板減少性-特発性, 紫斑病-血小板減少性-自己免疫性, 血小板減少性紫斑病-特発性
Swedish Purpura, trombocytopen, idiopatisk
Czech autoimunitní trombocytopenická purpura, purpura trombocytopenická idiopatická, Werlhofova nemoc, Idiopatická trombocytopenická purpura, Idiopatická purpura, ITP, Werlhofův syndrom
Finnish Idiopaattinen trombosytopeeninen purppura
Russian IDIOPATICHESKAIA TROMBOTSITOPENICHESKAIA PURPURA, AUTOIMMUNNAIA TROMBOTSITOPENICHESKAIA PURPURA, PURPURA TROMBOTSITOPENICHESKAIA IDIOPATICHESKAIA, PURPURA TROMBOTSITOPENICHESKAIA AUTOIMMUNNAIA, VERL'GOFA BOLEZN', АУТОИММУННАЯ ТРОМБОЦИТОПЕНИЧЕСКАЯ ПУРПУРА, ВЕРЛЬГОФА БОЛЕЗНЬ, ИДИОПАТИЧЕСКАЯ ТРОМБОЦИТОПЕНИЧЕСКАЯ ПУРПУРА, ПУРПУРА ТРОМБОЦИТОПЕНИЧЕСКАЯ АУТОИММУННАЯ, ПУРПУРА ТРОМБОЦИТОПЕНИЧЕСКАЯ ИДИОПАТИЧЕСКАЯ
Korean 특발성 혈소판 감소성 자색반증
Croatian PURPURA, IDIOPATSKA TROMBOCITOPENIČNA
Polish Immunotrombocytopenia samoistna, Małopłytkowość przewlekła, Plamica małopłytkowa idiopatyczna, Małopłytkowość samoistna, Choroba Werlhofa, Choroba Franka, Plamica małopłytkowa samoistna, Plamica małopłytkowa autoimmunologiczna, Małopłytkowość ostra
Hungarian idiopathiás thrombocytopeniás purpura, Werlhof-syndroma, Idiopathiás purpura, ITP
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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