II. Indications
III. Efficacy of oral dosing
- Oral B12 absorption via non-Intrinsic Factor pathway
- Large daily oral dose (1000 to 2000 mcg/day) is as effective as Parenteral (after 1 to 4 months)
- References
IV. Dosing: Vitamin B12 Deficiency
-
Cyanocobalamin tablets
- Preparations: 25 mcg, 50 mcg, 100 mcg, 250 mcg tablet
- Initial: 2000 mcg PO daily for 2 weeks to 4 months
- Maintenance: 1000 mcg PO daily
-
Cyanocobalamin nasal gel 500 mcg each week
- Preparations: 400 ug/0.1 ml nasal gel
- Initial: 1500 mcg weekly intranasally for 3-4 weeks
- Maintenance: 500 mcg weekly
-
Cyanocobalamin injection
- Initial: 1000 mcg IM daily for 2 weeks
- Maintenance: 1000 mcg IM every 1-3 months