II. Indications

  1. Cerebrovascular Accident Prevention
  2. Alternative for Aspirin sensitive patient
    1. Use Dipyridamole alone (Aggrenox contains Aspirin)

III. Mechanism

  1. Inhibits platelet aggregation
  2. Dipyridamole acts at platelet phosphodiesterase

IV. Dosing

  1. Dipyridamole (Persantine)
    1. Dose: 75 mg PO qid
  2. Aggrenox (Dipyridamole 200 mg and Aspirin 25 mg)
    1. Dose: 1 capsule bid

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Cost: Medications

dipyridamole (on 4/19/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
DIPYRIDAMOLE 25 MG TABLET Generic $0.22 each
DIPYRIDAMOLE 50 MG TABLET Generic $0.32 each
DIPYRIDAMOLE 75 MG TABLET Generic $0.49 each
aggrenox (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
AGGRENOX 25 MG-200 MG CAPSULE Generic $4.03 each

Ontology: Dipyridamole (C0012582)

Definition (NCI_NCI-GLOSS) A drug that prevents blood cell clumping and enhances the effectiveness of fluorouracil and other chemotherapeutic agents.
Definition (NCI) A synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen. (NCI04)
Definition (MSH) A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Definition (CSP) platelet inhibitor and coronary vasodilator used to prevent thromboembolism associated with mechanical heart valves, as prophylactic adjunct in the prevention of myocardial reinfarction, and as a diagnostic aid adjunct in myocardial perfusion imaging; administered orally and intravenously.
Definition (PDQ) A synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39229&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39229&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C445" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004176
SnomedCT 387371005, 66859009
LNC LP14715-4, LP35684-7, MTHU001809
English Dipyramidole, Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-, 2,2',2'',2''''-[(4,8-Dipiperidinopyrimido-[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol, dipyridamole, DP, dipyridamole (medication), DIPYRIDAMOLE, Dipyridamole [Chemical/Ingredient], dipyramidole, Dipyridamole (product), Dipyridamole (substance), Dipyridamole
Swedish Dipyridamol
Czech dipyridamol
Finnish Dipyridamoli
Russian PERSANTIN, DIPIRIDAMOL, KURANTIL, ДИПИРИДАМОЛ, КУРАНТИЛ, ПЕРСАНТИН
Japanese ジピリダモール
Italian Dipiramidolo, Dipiridamolo
Polish Dipirydamol
Spanish dipiridamol (producto), dipiridamol (sustancia), dipiridamol, Dipiridamol
French Dypyridamole
German Dipyridamol
Portuguese Dipiridamol

Ontology: Persantine (C0700020)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004176
English Persantin, persantin, persantine, Persantine, Boehringer Ingelheim Brand of Dipyridamole

Ontology: Aggrenox (C0732282)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C047634
English Aggrenox, aggrenox