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Coagulopathy in Pregnancy

Aka: Coagulopathy in Pregnancy, Pregnancy Related Coagulopathy

Labs: Coagulation studies
1. ProTime (PT)
2. Partial Thromboplastin Time (PTT)
3. Fibrin split products (Fibrin Degradation Products)
4. Fibrinogen
5. Clot Test (4-8 minutes is normal clotting time)
Management: General
1. Specific underlying coagulopathy cause
2. Replace Fluids
3. Replace Coagulation deficits
Management: Fresh Frozen Plasma (1 unit) Indications
1. Fibrinogen <100 mg/dl
  1. FFP 1 unit increases Fibrinogen 10 mg/dl
2. Partial Thromboplastin Time (PTT) >60
3. ProTime >18 (INR >3)
4. Following every 5-6 platelets transfused
5. Following every 4-8 units packed RBCs transfused
Management: Packed Red Blood Cell (1 unit) Indications
1. Hematocrit below 27 to 30%
2. One unit packed RBC will increase Hematocrit 3%
3. Consider Fresh Frozen Plasma after 4-8 pRBC units
Management: Platelet (1 unit) Indications
1. Platelets <50,000
2. Platelets 1u will increase Platelets 5-10,000
3. Consider Fresh Frozen Plasma after 5-6 platelet units

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 10/21/2007 and last published on 5/17/2012.

This is one of 5740 pages in the Family Practice Notebook