Human Immunodeficiency Virus Book

http://www.fpnotebook.com/

IndinavirAka: Crixivan

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  1. Mechanism
    1. Protease Inhibitor
  2. Efficacy
    1. Very effective in combination with Zidovudine (AZT)
  3. Dosing
    1. Indinavir 600 mg PO tid ($360/month)
    2. Take on empty stomach
      1. One hour before or 2 hours after a meal
      2. Concurrent food reduces concentration up to 80%
    3. Drink at least 1.5 Liters liquid per day
      1. Drink 150 ml water per hour for 3 hours after dose
      2. Avoids Nephrolithiasis and Interstitial Nephritis
  4. Adverse Effects
    1. Well tolerated
    2. Indirect Bilirubin elevation in 10% of patients
    3. Nephrolithiasis in 2-3% of patients
  5. Drug Interactions
    1. St. John's Wort
      1. May reduce Indinavir concentrations by 80%
      2. Piscitelli (2000) Lancet 355:547

Indinavir (C0376637)

Definition (MSH)A potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
Definition (NCI)A drug that interferes with the ability of a virus to make copies of itself.
Definition (CSP)potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
Definition (NCI)A synthetic antiviral agent. Indinavir selectively inhibits human immunodeficiency virus (HIV) protease, an essential enzyme for replication and maturation of viral particles. HIV protease inhibition prevents the normal cleavage of gag-pol viral polyproteins, resulting in the release of immature, noninfectious virions and protection of healthy host cells. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD019469
EnglishIDV, Indinavir, INDINAVIR PREPARATION
Spanishindinavir
Parent ConceptsAntiviral Agents (C0003451), Protease Inhibitor (C0033607), Pyridines (C0034255), Anti-HIV Agents (C0376565), Retroviral protease inhibitor (C1268897), Drug allergen (C1320237), HIV Protease Inhibitors (C0162714)
SourcesCSP, LNC, MSH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Crixivan (C0701105)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD019469
EnglishCrixivan
SourcesCSP, MSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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