II. Preparations

  1. Emtricitabine (Emtriva, Coviracil)
  2. Emtricitabine with Tenofovir (Truvada TDF or Descovy TAF)

IV. Adverse Effects: Emtricitabine alone

  1. See nRTI for adverse effects attributed to the class
  2. Minimal specific adverse effects and well tolerated
  3. Hyperpigmentation of palms and soles
  4. Hepatitis B infection flares on withdrawal of medication

V. Adverse Effects: Emtricitabine with Tenofovir (Truvada, Descovy)

  1. See Tenofovir
  2. Start-up syndrome (Nausea, Abdominal Pain, Flatulence, Headache) which typically resolves after the first month
  3. Hepatitis B Virus flare
    1. Associated with abrupt cessation of Antiretroviral therapy
  4. Acute Renal Failure
    1. Risk when Truvada is combined with multiple dose or high dose NSAIDs
    2. May be less risk with Descovy (uses Tenofovir TAF instead of TDF)

VI. Protocol: HIV Prevention

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Cost: Medications

truvada (on 1/1/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
TRUVADA 200 MG-300 MG TABLET $47.28 each
emtriva (on 4/20/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
EMTRIVA 200 MG CAPSULE $17.11 each
descovy (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
DESCOVY 200-25 MG TABLET $47.02 each

Ontology: emtricitabine (C0909839)

Definition (NCI) A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group).
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C122114
SnomedCT 404855005, 404856006
LNC LP35786-0, MTHU018643
English 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-, FTC, emtricitabine, emtricitabine (medication), EMTRICITABINE, emtricitabine [Chemical/Ingredient], beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine, Emtricitabine (product), Emtricitabine (substance), Emtricitabine
Spanish emtricitabina (producto), emtricitabina (sustancia), emtricitabina