II. Mechanism

III. Adverse Effects

  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Indirect Hyperbilirubinemia
  3. Rash (20%)
    1. Does not typically require stopping the medication
  4. Nephrolithiasis
  5. EKG Abnormalities
    1. PR prolongation
    2. Other cardiac conduction abnormalities

IV. Dosing

  1. Take with food

V. Drug Interactions

  1. Acid suppressants (Proton Pump Inhibitors, H2 Blockers)
    1. Proton Pump Inhibitors renders Atrazanavir ineffective and results in a high risk of developing resistance
    2. Atrazanavir requires acid in Stomache for absorption

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