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Drug Reaction in HIVAka: Hypersensitivity and Pruritic Syndrome

Mechanism
1. Increased Incidence hypersensitivity cutaneous reaction
Etiology: Medication Reaction
1. NNRTI's (especially Nevirapine)
2. Abacavir (Ziagen)
  1. nRTI with life-threatening Hypersensitivity Reaction
3. Sulfa
4. Dapsone
Differential Diagnosis
1. See HIV Related Rash
Signs
1. Mild-Moderate reactions
  1. Maculopapular eruptions
  2. Urticaria
  3. Fixed Drug Eruptions
2. Severe reactions
  1. Exfoliative erythroderma
  2. Erythema Multiforme
  3. Stevens-Johnson Syndrome
Management
1. Not usually necessary to discontinue offending drug
  1. Spontaneous resolution in 70-80% cases in 7-10 days
  2. Serious reactions require drug discontinuation
2. Antipruritics
3. Antipyretics

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 5/10/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.