III. Causes: Medication adverse effects

  1. Direct cardiotoxicity
    1. Abacavir (Ziagen)
  2. Dyslipidemia or Lipodystrophy
    1. Protease Inhibitors

IV. Findings

  1. Common
    1. Coronary Artery Disease
      1. Longstanding HIV carries a coronary disease equivalent risk similar to Diabetes Mellitus
      2. CD4 Count <500 is associated with an increased risk of coronary events (even if it rebounds)
    2. Dilated Cardiomyopathy (25% advanced HIV)
    3. Left Ventricular Dysfunction (21% advanced HIV)
    4. Myocardial fibrosis
      1. Present in up to 82% of HIV patients and often asymptomatic
  2. Less common
    1. Myocarditis
    2. Pericardial Effusion
    3. Pericarditis
    4. Arrhythmias
  3. Rare Conditions
    1. Endocarditis

V. Symptoms

  1. Most are asymptomatic

VI. Signs

  1. Usually clinically silent
  2. Pericardial Effusions (usually sterile) in 25%

VII. Management

VIII. Reference

  1. Mathieu (April, 2000) Federal Practitioner, p. 18-20
  2. Swaminathan and Bafuma in Herbert (2017) EM:Rap 17(3): 2

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Ontology: HIV cardiomyopathy (C2721728)

Concepts Disease or Syndrome (T047)
English HIV cardiomyopathy
Spanish Cardiomiopatía por VIH
Portuguese VIH com cardiomiopatia
French Cardiomyopathie VIH
Italian Cardiomiopatia HIV-relativa
German HIV-Kardiomyopathie
Dutch HIV-cardiomyopathie
Czech HIV kardiomyopatie
Japanese HIV心筋症, HIVシンキンショウ
Hungarian HIV cardiomyopathia