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Factor V LeidenAka: Factor 5 Leiden, Activated Protein C resistance, APC Resistance
- Epidemiology
- Responsible for 20-50% of Hypercoagulable patients
- Incidence of Autosomal dominant genetic defect
- Europeans: 15%
- North America: 3-5%
- Risks
- Heterozygote: 5-10 times the risk of thrombosis
- Homozygote: 50-100 times the risk of thrombosis
- Pathophysiology
- Factor V is a cofactor for Factor X
- Defect prevents Factor V degradation by Protein C
- Labs
- Activated Protein C (APC) resistance
- Can not be anticoagulated when this lab run
- PCR for Factor V Leiden
- Responsible for 95% of APC Resistance
- Does NOT require that patient be off Anticoagulation
- Complications
- Deep Vein Thrombosis
- Pulmonary Embolism
- Myocardial Infarction
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