Hematology and Oncology Book

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Glycoprotein IIB/IIIA InhibitorAka: GP IIB/IIA Inhibitor, Abciximab, ReoPro, Tirofiban, Aggrastat, Eptifibatide, Integrilin

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  1. Indications
    1. Non-Q-Wave Myocardial Infarction
    2. High risk Unstable Angina
    3. Angioplasty
  2. Mechanism
    1. Inhibits platelet aggregation
  3. Dosing: Abciximab (ReoPro)
    1. Load: 0.25 mg/kg IV bolus
    2. Infuse: 0.125 ug/kg/min up to 10 ug/min IV x12 hours
  4. Dosing: Eptifibatide (Integrilin)
    1. Acute Coronary Syndrome
      1. Load: 180 ug/kg
      2. Infuse: 2 ug/kg/min IV x72 hours
    2. Angioplasty
      1. Load: 135 ug/kg IV before procedure
      2. Infuse: 0.5 ug/kg/min IV x24 hours
  5. Dosing: Tirofiban (Aggrastat)
    1. Load: 0.4 ug/kg/min for 30 minutes
    2. Infuse: 0.1 ug/kg/min
    3. Infusion duration
      1. Acute Coronary Syndrome: 48 to 108 hours
      2. Angioplasty: 12 to 24 hours

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