Hematology and Oncology Book

http://www.fpnotebook.com/

ClopidogrelAka: Plavix

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  1. Mechanism
    1. Blocks Platelet ADP
    2. Inhibits platelet aggregation
  2. Indications
    1. Cerebrovascular Accident Prevention
    2. Coronary Artery Disease Prevention
  3. Advantages
    1. Less adverse effects than Ticlid
    2. Less GI Bleeding than Aspirin
      1. Option if GI Bleeding occurs with Aspirin
      2. Switch to Plavix does not prevent recurrent GI Bleed
        1. GI Bleed occurs in 8% of those switched to Plavix
        2. Consider adding PPI to Aspirin instead of Plavix
  4. Disadvantages
    1. Expensive ($125/month)
  5. Dosing
    1. Plavix 75 mg PO qd
  6. Protocol: Perioperative
    1. Stop 7 days before surgery

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