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Von Willebrand's Disease
- Epidemiology
- Most common inherited Bleeding Disorder
- Mild Bleeding Disorder (often undiagnosed)
- Autosomal dominant disorder
- Pathophysiology
- Von Willebrand factor mediates platelet adhesion
- vWF Deficiency results in mucocutaneous bleeding
- Symptoms and Signs
- Severe Menorrhagia (common presentation in women)
- Postpartum Hemorrhage several days after delivery
- Labs
- Lab Results vary over time in each patient
- Partial Thromboplastin Time (PTT) prolonged
- Bleeding Time prolonged
- Platelet Function Closure Time (PFCT)
- Replaces Bleeding Time
- Management
- Synthetic hormone arginine vasopressin (DDAAVP)
- Indicated for surgery or trauma
- Cryoprecipitate
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