II. Definition: Hair-AN Acronym

III. Pathophysiology

  1. Primary abnormality
    1. Insulin Resistance causes increased Insulin
  2. Secondary abnormality
    1. Excess androgen secretion from ovaries

IV. Associated Conditions

VI. Labs

  1. General lab testing
    1. Complete Blood Count (CBC)
    2. Thyroid Stimulating Hormone (TSH)
    3. Serum Prolactin
    4. Serum electrolytes (Chem7)
  2. Labs associated with Insulin Resistance
    1. Fasting Serum Glucose
    2. Consider Glucose Tolerance Test
  3. Labs associated with Androgen Excess
    1. See Hyperandrogenism

VII. Management

  1. General Measures
    1. Weight loss
    2. See Hirsutism
  2. Gonadotropin suppression
    1. Oral Contraceptives (low Androgenic Activity)
      1. Desogestrel (Desogen)
      2. Norgestimate (Ortho-Cyclen)
    2. Anti-androgens
      1. Spironolactone (Aldactone) 50 to 100 mg po bid
      2. Flutamide (Eulexin)
        1. Risk of hepatotoxicity
      3. Finasteride (Proscar) 5 mg per day
  3. Insulin Resistance Modifier
    1. Glucophage (Metformin) 500 - 850 mg PO qd to bid

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Ontology: HAIR-AN syndrome (C1963745)

Concepts Disease or Syndrome (T047)
MSH C537629
Spanish Síndrome HAIR-AN
French Syndrome HAIR-AN
Dutch HAIR-AN-syndroom
Portuguese Síndrome de HAIR-AN
German HAIR-AN Syndrom
Italian Sindrome HAIR-AN
Japanese HAIR−AN症候群, HAIRANショウコウグン
Czech Syndrom HAIR-AN
English HAIR-AN syndrome, Hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN), Hyperandrogenic, insulin-resistant acanthosis nigricans syndrome
Hungarian HAIR-AN syndroma