I. Definition

  1. Wart-like benign Breast tissue growth within the Lactation ducts

II. Epidemiology

  1. Peak Incidence: age 35-55 years old (mean age 48 years old)

III. Pathophysiology

  1. Mechanism of growth appears to be proliferative fibrocystic epithelial hyperplasia
  2. Broad-based or pedunculated polypoid epithelial growth of size 2-3 mm and within Lactation duct
  3. Localized within 1 cm of nipple in 90% of cases

IV. Symptoms

  1. Nipple Discharge (clear or bloody)

V. Imaging

  1. Mammogram
    1. Typically normal
  2. Breast Ultrasound
    1. May demonstrate Intraductal Papilloma

VI. Diagnosis

  1. Breast biopsy
    1. Distinguishes Intraductal Papilloma from Breast Cancer as a cause of bloody Breast discharge

VII. Complications

  1. Breast cysts
    1. Related to Lactation duct obstruction by papilloma

VIII. Prognosis

  1. Solitary Intraductal Papilloma
    1. Benign growths, but do confer a 1.5 to 2 fold increased lifetime risk of Breast Cancer
  2. Multiple Intraductal Papillomas
    1. Considered premalignant condition (similar risk to lobular carcinoma in situ or LCIS) with lifetime relative Breast Cancer risk of 7.4
    2. Multiple papillomas have a predisposition for terminal lobular ducts where ductal carcinoma frequently arises

Images: Related links to external sites (from Google)

Ontology: Intraductal papilloma of breast (C0238034)

Definition (NCI) A benign (not cancer), wart-like growth in a milk duct of the breast. It is usually found close to the nipple and may cause a discharge from the nipple. It may also cause pain and a lump in the breast that can be felt. It usually affects women aged 35-55 years. Having a single papilloma does not increase the risk of breast cancer. When there are multiple intraductal breast papillomas, they are usually found farther from the nipple. There may not be a nipple discharge and the papillomas may not be felt. Having multiple intraductal breast papillomas may increase the risk of breast cancer.
Definition (NCI) A benign neoplasm arising from the ductal breast epithelium. --2003
Concepts Neoplastic Process (T191)
SnomedCT 254848002
English BREAST, PAPILLOMA, INTRACYSTIC, BREAST, PAPILLOMA, INTRADUCTAL, benign intraductal papilloma of breast, benign intraductal papilloma of breast (diagnosis), Intraductal papilloma of breast, duct papilloma of breast, intraductal papilloma breast, breast intraductal papilloma, breast intraductal papillomas, breast duct papilloma, intraductal breast papilloma, Duct papilloma of breast, Intraduct papilloma of breast, Duct papilloma of breast (disorder), Duct Papilloma of Breast, Duct Papilloma of the Breast, Ductal Breast Papilloma, Intraductal Breast Papilloma, Intraductal Papilloma of Breast, Intraductal Papilloma of the Breast, Papilloma of Breast, Papilloma of the Breast, Breast Papilloma
Italian Papilloma intraduttale della mammella
Japanese 乳管内乳頭腫, ニュウカンナイニュウトウシュ
Czech Intraduktální papilom prsu
Hungarian Emlő intraductalis papilloma
Spanish papiloma ductal de mama, papiloma mamario intraductal (trastorno), papiloma mamario intraductal, Papiloma intraductal de mama
Portuguese Papiloma intracanicular da mama
Dutch intraductaal papilloom van de borst
French Papillome intracanalaire du sein
German intraduktales Papillom der Brustdruese