Gastroenterology Book

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Glyceryl trinitrate

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  1. Indication
    1. Anal Fissure
  2. Mechanism
    1. Reduces maximal anal resting pressure
  3. Dosing
    1. Glyceryl trinitrate ointment 0.2% bid for 6 weeks
  4. Efficacy
    1. Study of 80 patients with Anal Fissures
      1. At 8 weeks, fissures healed in 68% versus 8% Placebo
    2. References
      1. Lund (1997) Lancet :

Nitroglycerin (C0017887)

Definition (MSH)A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Definition (CSP)volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium; an explosive compound rendered safe when compounded in tablets with mannitol.
Definition (NCI)An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishGlyceryl Trinitrate, Glyceryl trinitrate product, Nitroglycerin, NITROGLYCERIN PREPARATION, nitroglycerine, Nitroglycerol
Spanishgliceriltrinitrato, nitroglicerina, nitroglicerol, trinitrato de glicerilo
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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