Gastroenterology Book

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Amitiza

Aka: Amitiza, Lubiprostone
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  1. Dosing
    1. Irritable Bowel Syndrome with Constipation: 8 mcg PO bid
    2. Chronic Constipation: 24 mcg PO bid
  2. Adverse Effects
    1. Nausea (with 24 mcg dose)
    2. Diarrhea (with 24 mcg dose)
    3. Chest Pain or Dyspnea
      1. Follows dose within 1 hour
      2. Resolves within 3 hours
  3. Disadvantages
    1. Low efficacy in Irritable Bowel Syndrome with Constipation: Only 14% respond
    2. Expensive: $200 per month
  4. Mechanism
    1. ClC(2) chloride channel opener
  5. References
    1. Chang (2006) Curr Treat Options Gastroenterol 9(4):314-23
Medication Costs
Amitiza (on 2/9/2012 at DrugStore.com)
Amitiza 8mcg Capsules #60 for $258.98 ($4.32/unit)
Amitiza 24mcg Capsules #30 for $130.80 ($4.36/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

lubiprostone (C1684405)

Concepts Eicosanoid (T111) , Pharmacologic Substance (T121)
MSH C506401
SnomedCT 420304008, 421856003
English Lubiprostone, Lubiprostone (product), Lubiprostone (substance), 7-((1R,4R,6R,9R)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo(4.3.0)non-9-yl)heptanoic acid, Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11alpha)-, lubiprostone (medication), lubiprostone [Chemical/Ingredient], LUBIPROSTONE, lubiprostone
Spanish lubiprostona, lubiprostona (producto), lubiprostona (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Amitiza (C1699150)

Concepts Lipid (T119) , Pharmacologic Substance (T121)
MSH C506401
English Amitiza
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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