Gastroenterology Book

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Autoimmune Hepatitis

Aka: Autoimmune Hepatitis
  1. Epidemiology
    1. Much more common in women than in men
  2. Labs
    1. Transaminases Moderately elevated
      1. Alanine Aminotransferase (ALT) 150-1000
      2. Aspartate Aminotransferase (AST) 150-1000
    2. Cholestasis Labs elevated
      1. Gamma glutamyl transferase (GGT) elevated
      2. Alkaline Phosphatase
    3. Liver Function Tests abnormal
      1. Albumin depressed
      2. ProTime prolonged
      3. Bilirubin elevated
  3. Diagnosis
    1. Exclude other liver disease
    2. Specific Labs (False Negative: 10-20%)
      1. Antinuclear Antibody (ANA)
      2. Smooth Muscle Antibody (SMA)
      3. Anti-LKM Antibody
  4. Management
    1. See Prevention of Liver Disease Progression
    2. Corticosteroids
      1. Significantly improve survival
  5. Course
    1. Severe progressive liver disease is more typical

Hepatitis, Autoimmune (C0241910)

Definition (MSH) A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
Concepts Disease or Syndrome (T047)
MSH D019693
English Autoimmune chronic active hepatitis, Autoimmune hepatitis
Spanish hepatitis activa cronica autoinmune, hepatitis autoinmune, hepatitis autoinmunitaria
Parent Concepts Autoimmune Diseases (C0004364), Hepatitis, Chronic (C0019189), Hepatitis (C0019158), Autoimmune liver disease (C0400936)
Sources DXP , MSH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


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