Gastroenterology Book

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Autoimmune Hepatitis

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  1. Epidemiology
    1. Much more common in women than in men
  2. Labs
    1. Transaminases Moderately elevated
      1. Alanine Aminotransferase (ALT) 150-1000
      2. Aspartate Aminotransferase (AST) 150-1000
    2. Cholestasis Labs elevated
      1. Gamma glutamyl transferase (GGT) elevated
      2. Alkaline Phosphatase
    3. Liver Function Tests abnormal
      1. Albumin depressed
      2. ProTime prolonged
      3. Bilirubin elevated
  3. Diagnosis
    1. Exclude other liver disease
    2. Specific Labs (False Negative: 10-20%)
      1. Antinuclear Antibody (ANA)
      2. Smooth Muscle Antibody (SMA)
      3. Anti-LKM Antibody
  4. Management
    1. See Prevention of Liver Disease Progression
    2. Corticosteroids
      1. Significantly improve survival
  5. Course
    1. Severe progressive liver disease is more typical

Hepatitis, Autoimmune (C0241910)

Definition (MSH)A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
ConceptsDisease or Syndrome (T047)
MSHD019693
EnglishAutoimmune chronic active hepatitis, Autoimmune hepatitis
Spanishhepatitis activa cronica autoinmune, hepatitis autoinmune, hepatitis autoinmunitaria
Parent ConceptsAutoimmune Diseases (C0004364), Hepatitis, Chronic (C0019189), Hepatitis (C0019158), Autoimmune liver disease (C0400936)
SourcesDXP, MSH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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