Primary carcinoma of the liver cells (C0019204)
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| Definition (MSH) | A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. |
| Definition (NCI) | (HEP-a-toe-SEL-yoo-ler kar-sin-O-ma) A type of adenocarcinoma, the most common type of liver tumor. |
| Definition (NCI) | (hep-a-TOE-ma) A liver tumor. |
| Definition (CSP) | primary malignant neoplasm of epithelial liver cells; it ranges from a well-differentiated tumor with epithelial cells indistinguishable from normal hepatocytes to a poorly differentiated neoplasm; the cells may be uniform or markedly pleomorphic, or form giant cells; associations exist with chronic hepatitis B virus infection, some types of cirrhosis, and hepatitis C virus infection. |
| Definition (NCI) | A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. --2002 |
| Concepts | Neoplastic Process (T191)
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| ICD9 | 155.0 |
| English | CARCINOMA LIVER, CARCINOMA OF LIVER, Carcinoma of liver cell, Carcinoma of Liver Cells, Carcinoma of the Liver Cells, HCC, Hepatic Carcinoma, Hepatocarcinoma, Hepatocellular Carcinoma, Hepatocellular Carcinomas, HEPATOMA, Hepatomas, LIVER CARCINOMA, Liver cell carcinoma, Malignant hepatoma, Primary carcinoma of liver, Primary Carcinoma of Liver Cells, Primary carcinoma of the liver cells |
| Spanish | carcinoma de células hepáticas, carcinoma de celulas hepaticas, carcinoma hepatocÃtico, carcinoma hepatocelular, carcinoma hepatocitico, carcinoma primario del hÃgado, carcinoma primario del higado, hepatocarcinoma, hepatoma |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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