Endocrinology Book

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Prolactinoma

Aka: Prolactinoma
  1. Epidemiology
    1. Most common pituitary tumor
  2. Symptoms
    1. Galactorrhea
    2. Amenorrhea
    3. Infertility
    4. Decreased libido
  3. Labs
    1. Serum Prolactin > 100 to 200 ng/ml (typically >200 ng/ml)
  4. Radiology
    1. MRI Head with cone-down view of sella turcica
  5. Differential Diagnosis
    1. See Hyperprolactinemia
  6. Management
    1. Macroadenoma (>10 mm in diameter)
      1. Suprasellar (may compress optic chiasm)
        1. Infertility: Bromocriptine or Surgery
        2. Amenorrhea: Bromocriptine or Cabergoline or Surgery
      2. Intrasellar
        1. Infertility: Bromocriptine
        2. Amenorrhea: Bromocriptine or Cabergoline
    2. Microadenoma (<10 mm in diameter)
      1. No treatment needed if Menses regular
      2. Infertility: Bromocriptine
      3. Amenorrhea
        1. Bromocriptine (Parlodel) or
        2. Cabergoline (Dostinex) or
        3. Oral Contraceptive
  7. References
    1. Molitch (2001) Endocrinol Metab Clin North Am 30:585
    2. Schlechte (2003) N Engl J Med 349:2035-41

Prolactinoma (C0033375)

Definition (MSH) A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Definition (NCI) An adenoma of the anterior lobe of the pituitary gland that produces prolactin. It is the most common type of pituitary gland adenomas and it is associated with hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, impotence, headache, and visual disturbances.
Concepts Neoplastic Process (T191)
MSH D015175
ICD10 M8271/0
SnomedCT 367098005, 34337008, 134209002
English Adenoma, Prolactin-Secreting, Pituitary, Pituitary Adenoma, PRL-Secreting, Pituitary Adenoma, Prolactin-Producing, Pituitary Adenoma, Prolactin-Secreting, Pituitary Adenomas, PRL-Secreting, Pituitary Adenomas, Prolactin-Producing, Pituitary Adenomas, Prolactin-Secreting, PRL Secreting Pituitary Adenoma, PRL-Secreting Pituitary Adenoma, PRL-Secreting Pituitary Adenomas, Prolactin-Producing Pituitary Adenoma, Prolactin-Producing Pituitary Adenomas, Prolactin-Secreting Pituitary Adenomas, Prolactinomas, PITUITARY ADENOMA, PROLACTIN SECRETING, PROLACTINOMA, Pituitary Adenoma, Prolactin Secreting, PITUITARY NEOPLASM (PROLACTINOMA), Prolactin Producing Pituitary Gland Adenoma, Prolactin Secreting Pituitary Gland Adenoma, PRL Producing Pituitary Gland Adenoma, prolactinoma, prolactinoma of pituitary gland (diagnosis), prolactinoma of pituitary gland, pituitary prolactinoma, Prolactin-secret pit adenoma, PITUITARY PROLACTINOMA, PROLACTINOMA, FAMILIAL, PITUITARY ADENOMA, PROLACTIN-SECRETING, Prolactinoma, Prolactinoma [Disease/Finding], prolactinomas, adenoma prolactin secreting, pituitary prolactinomas, [M] Prolactinoma, Prolactinoma (morphologic abnormality), [M]Prolactinoma, Prolactin-secreting pituitary adenoma, Prolactinoma (disorder), prolactin secreting adenoma, adenoma, prolactin secreting, prolactinoma; unspecified site, Prolactin Producing Pituitary Adenoma, Prolactin Secreting Pituitary Adenoma, Pituitary Gland Prolactinoma, Pituitary Prolactinoma, Prolactin Producing Adenoma of Pituitary Gland, Prolactin Producing Adenoma of Pituitary, Prolactin Producing Adenoma of the Pituitary Gland, Prolactin Producing Adenoma of the Pituitary, Prolactin Secreting Adenoma of Pituitary Gland, Prolactin Secreting Adenoma of Pituitary, Prolactin Secreting Adenoma of the Pituitary Gland, Prolactin Secreting Adenoma of the Pituitary, Prolactin Secreting Adenoma, Prolactinoma of Pituitary Gland, Prolactinoma of Pituitary, Prolactinoma of the Pituitary Gland, Prolactinoma of the Pituitary, Prolactin-Secreting Pituitary Adenoma, Lactotroph Adenomas, Lactotroph Adenoma, Adenoma, Lactotroph, Adenomas, Lactotroph
Swedish Prolaktinom
Japanese ﾌﾟﾛﾗｸﾁﾝｻﾝｾｲｼｭﾖｳ, PRL産生下垂体腺腫, プロラクチノーマ, PRL分泌下垂体腺腫(PRLブンピツカスイタイセンシュ), プロラクチン分泌下垂体腺腫(プロラクチンブンピツカスイタイセンシュ), プロラクチン産生下垂体腫瘍, プロラクチン産生下垂体腺腫, PRL分泌下垂体腺腫, PRL産生腺腫, Prolactin分泌腫瘍, Prolactin産生腫瘍, プロラクチン分泌下垂体腺腫, プロラクチン分泌腫瘍, プロラクチン産生腫瘍, プロラクチン産生腺腫, 下垂体腺腫-プロラクチン分泌, 下垂体腺腫-プロラクチン産生, 腺腫-プロラクチン分泌-下垂体
Czech prolaktinom, Prolaktinom
Spanish Prolactinoma, (M)prolactinoma, prolactinoma (anomalía morfológica), prolactinoma, prolactinoma (trastorno), Adenoma Pituitario Secretor de PRL, Adenoma Pituitario Secretor de Prolactina, Adenoma Pituitario Secretorio de Prl, Adenoma Pituitario Secretorio de Prolactina
Finnish Prolaktinooma
Russian PROLAKTINOMA, ADENOMA PROLAKTINSEKRETIRUIUSHCHAIA GIPOFIZARNAIA, GIPOFIZARNAIA ADENOMA PROLAKTINSEKRETIRUIUSHCHAIA, PROLAKTINPRODUTSIRUIUSHCHAIA ADENOMA GIPOFIZA, PROLAKTINSEKRETIRUIUSHCHAIA ADENOMA GIPOFIZA, АДЕНОМА ПРОЛАКТИНСЕКРЕТИРУЮЩАЯ ГИПОФИЗАРНАЯ, ГИПОФИЗАРНАЯ АДЕНОМА ПРОЛАКТИНСЕКРЕТИРУЮЩАЯ, ПРОЛАКТИНОМА, ПРОЛАКТИНПРОДУЦИРУЮЩАЯ АДЕНОМА ГИПОФИЗА, ПРОЛАКТИНСЕКРЕТИРУЮЩАЯ АДЕНОМА ГИПОФИЗА
Italian Adenoma ipofisario prolattina-secernente, Adenoma lattotropo, Adenoma ipofisario PRL-secernente, Adenomi ipofisari che producono prolattina, Prolattinoma
Croatian PROLAKTINOM
Polish Prolaktynoma, Gruczolak przysadki wydzielający prolaktynę
Hungarian Prolactinoma
Dutch prolactinoom; niet gespecificeerde lokalisatie, prolactinoom, Adenoom, prolactinesecernerend hypofysair, Hypofyseadenoom, prolactinesecernerend, Prolactinoom
French Prolactinome, Adénome lactotrope, Adénome à prolactine, Adénome hypophysaire sécrétant la PRL, Adénome hypophysaire sécrétant la prolactine
German Adenom, prolaktinsezernierendes, Hypophysen-, Hypophysenadenom, prolaktinsezernierendes, PRL-sezernierendes Hypophysenadenom, Prolaktinom, Prolaktinproduzierendes Hypophysenadenom
Portuguese Prolactinoma, Adenoma Pituitário Secretor de PRL, Adenoma Pituitário Secretor de Prolactina, Adenoma Pituitário Secretório de Prl, Adenoma Pituitário Secretório de Prolactina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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