Endocrinology Book

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Prolactinoma

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  1. Epidemiology
    1. Most common pituitary tumor
  2. Symptoms
    1. Galactorrhea
    2. Amenorrhea
    3. Infertility
    4. Decreased libido
  3. Labs
    1. Serum Prolactin > 100 to 200 ng/ml
  4. Radiology
    1. MRI Head with cone-down view of sella turcica
  5. Differential Diagnosis
    1. See Hyperprolactinemia
  6. Management
    1. Macroadenoma (>10 mm in diameter)
      1. Suprasellar (may compress optic chiasm)
        1. Infertility: Bromocriptine or Surgery
        2. Amenorrhea: Bromocriptine or Cabergoline or Surgery
      2. Intrasellar
        1. Infertility: Bromocriptine
        2. Amenorrhea: Bromocriptine or Cabergoline
    2. Microadenoma (<10 mm in diameter)
      1. No treatment needed if Menses regular
      2. Infertility: Bromocriptine
      3. Amenorrhea
        1. Bromocriptine (Parlodel) or
        2. Cabergoline (Dostinex) or
        3. Oral Contraceptive
  7. References
    1. Molitch (2001) Endocrinol Metab Clin North Am 30:585
    2. Schlechte (2003) N Engl J Med 349:2035

Prolactinoma (C0033375)

Definition (MSH)A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Definition (NCI)An adenoma of the anterior lobe of the pituitary gland that produces prolactin. It is the most common type of pituitary gland adenomas and it is associated with hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, impotence, headache, and visual disturbances.
ConceptsNeoplastic Process (T191)
MSHD015175
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Spanishprolactinoma
Parent Conceptsadenoma (C0001430), Pituitary Neoplasms (C0032019), Pituitary Adenoma (C0032000), prolactin-producing pituitary tumor (C0278863), Neuroendocrine Tumors (C0206754), Benign adenomatous neoplasm - category (C1302714), Duplicate concept (C1274013)
SourcesCOSTAR, CSP, DXP, MSH, NCI, NDFRT, OMIM, PDQ, QMR, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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