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Tay-Sachs DiseaseAka: Amaurotic Familial Idiocy
- See Also
- Lysosomal Storage Disease
- Inborn Errors of Metabolism
- Epidemiology
- Hereditary recessive trait
- Jews of eastern European origin
- Pathophysiology
- Inborn error of metabolism
- Abnormal metabolism of neuronal lipids
- Results in cerebral atrophy
- Symptoms
- Insidious onset at about 6 months of age
- Healthy infants develop progressive developmental delay
- Signs
- Initial Stages
- Decreased motor activity
- Flaccidity
- Apathy
- Inattentiveness
- Later Stages
- Spasticity
- Clonus
- Babinski with upgoing toes
- Convulsions
- Increasing Dementia
- Final Stages
- Blindness
- Idiocy
- Retinal cherry red spot of Macular Degeneration
- Course
- Death occurs in first 3-4 years
Amaurotic Familial Idiocy (C0282220)
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| Definition (MSH) | An outdated term for Tay-Sachs disease. |
| Concepts | Disease or Syndrome (T047)
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| ICD9 | 330.1 |
| English | Amaurotic Familial Idiocy, Familial Amaurotic Idiocy, Infantile amaurotic familial disease, INFANTILE AMAUROTIC FAMILIAL IDIOCY |
| Spanish | enfermedad familiar amaurótica, enfermedad familiar amaurótica infantil, enfermedad familiar amaurotica, enfermedad familiar amaurotica infantil, idiotez familiar amaurótica, idiotez familiar amaurotica |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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