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Toxin Antidotes

Aka: Toxin Antidotes

See Also
Management: Specific Antidotes for Analgesic overdoses
1. Salicylate Overdose (Salicylism)
  1. Alkalinize Urine
  2. Consider Dialysis
2. Acetaminophen Overdose
  1. N-Acetylcysteine (NAC, Mucomyst, PO or Neb, Acetadote IV) based on nomogram
3. Opioid Overdose (Narcotic Overdose)
  1. Naloxone
Management: Specific Antidotes for cardiovascular agent overdoses
1. See Beta Blocker Overdose
2. See Calcium Channel Blocker Overdose
3. See Clonidine Overdose
4. Digoxin
  1. Digoxin Immune Fab fragments (Digibind)
Management: Specific Antidotes for miscellaneous overdoses
1. Anticholinergics
  1. Physostigmine
2. Arsenic
  1. BAL chelation
  2. DMSA
3. Carbon Monoxide
  1. Oxygen
4. Cyanide
  1. Nitrites (Cyanokit, Sodium nitrite, Sodium thiosulfate)
  2. Hydroxycobalamin
  3. Oxygen
5. Fluoride
  1. Calcium
6. Hydrazines
  1. Pyridoxine
7. Iron
  1. Deferoxamine (Desferal)
8. Isoniazid (INH)
  1. Pyridoxine
9. Lead
  1. BAL chelation
  2. DMSA
  3. Succimer
10. Mercury
  1. Succimer
  2. DMSA
11. Methanol or Ethylene Glycol
  1. Ethanol 10%
  2. Fomepizole (Antizol)
12. Methemoglobinemia
  1. Methylene blue
13. Organophosphates or Cholinergics
  1. Atropine
  2. 2-PAMCl
14. Oxalates
  1. Calcium
15. Sulfonylurea
  1. See Sulfonylurea Overdose
  2. Octreotide (Sandostatin)
  3. Dextrose
  4. Glucagon (temporizing measure only)
16. Tricyclic Antidepressants overdose
  1. Sodium Bicarbonate to alkalinize the urine
  2. Benzodiazepines for Seizure (avoid other anticonvulsants)
17. Warfarin
  1. Vitamin K
  2. Fresh Frozen Plasma
References

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Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 12/21/2011 and last published on 2/5/2012.

This is one of 5663 pages in the Family Practice Notebook