Otolaryngology Book

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AphthasolAka: Amlexanox

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  1. Background
    1. Cost: $20/5g tube
  2. Indications
    1. Severe Aphthous Ulcers
  3. Mechanism: Reduces local inflammation
    1. Inhibits histamines
    2. Inhibits leukotrienes
  4. Efficacy
    1. Speeds up ulcer healing by 1 day
  5. Dosing
    1. Apply 1/4 inch oral paste to ulcer after meals and qhs
    2. Start as soon as symptom onset
    3. Use until ulcer heals up to 10 days

amlexanox (C0103049)

Definition (NCI)An anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishamlexanox, AMLEXANOX PREPARATION, amoxanox
Spanishamlexanox
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Aphthasol (C1097532)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishAphthasol, GlaxoSmithKline brand of amlexanox
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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