II. Pathophysiology

III. Symptoms

  1. Rash onset within four days of offending medication exposure

IV. Signs

  1. Fever
  2. Rash
    1. Onset at flexor surfaces (e.g. neck, axilla, antecubital fossa, popliteal fossa)
    2. Tiny, non-follicular Pustules

V. Causes

  1. Beta-lactam antibiotics (Penicillins, Cephalosporins, carbapenems)
  2. Macrolide antibiotics (e.g. Erythromycin, Azithromycin)
  3. Calcium Channel Blockers

VII. Management

  1. Eliminate the offending agent
  2. Consider Topical Corticosteroids

VIII. References

  1. Jhun and DeClerck in Herbert (2015) EM:Rap 15(2): 9-11

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